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AB121273

Anti-TRIO antibody

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(1 Publication)

Rabbit Polyclonal TRIO antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRIO aa 2550 to C-terminus.

View Alternative Names

Triple functional domain protein, PTPRF-interacting protein, TRIO

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIO antibody (AB121273)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIO antibody (AB121273)

ab121273 at 1/50 dilution staining TRIO in Paraffin-embedded Human Duodenum tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TRIO aa 2550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O75962

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIO also known as Triple Functional Domain Protein or Trio Rho guanine nucleotide exchange factor acts mechanically as a guanine nucleotide exchange factor. It facilitates the activation of the Rho family of small GTPases specifically Rac1 and RhoG. TRIO weighs approximately 349 kDa and is widely expressed in different tissues especially in the central nervous system. This protein modulates signal transduction associated with cytoskeletal dynamics cell migration and neuronal development.
Biological function summary

TRIO influences cellular processes like actin cytoskeleton organization and axonal outgrowth. It serves as part of multi-protein complexes that guide the intracellular signaling cascades. Particularly TRIO plays a central role in developmental pathways by promoting neuronal growth and differentiation through Rac1 activation. Its function is important for establishing the architecture of the nervous system.

Pathways

TRIO participates in key signal transduction pathways such as the Rho GTPase cycle and the axon guidance pathway. It acts in concert with other proteins like Rac1 and RhoG to regulate cell adhesion and neuronal pathfinding. Through these pathways TRIO contributes to the polarization and directional movement of cells which is necessary for proper tissue and organ development.

TRIO connects to several neurological conditions including intellectual disability and schizophrenia. Mutations in the TRIO gene as well as dysregulation of its related proteins can disrupt normal brain development and function. Particularly alterations in Rac1 and RhoG signaling have been implicated in these disorders linking TRIO to their pathogenesis and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed : 22155786, PubMed : 27418539, PubMed : 8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed : 10341202, PubMed : 22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed : 32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity).
See full target information TRIO
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of nanomedicine 19:2071-2090 PubMed38476275

2024

MSC-Derived Exosomes Mitigate Myocardial Ischemia/Reperfusion Injury by Reducing Neutrophil Infiltration and the Formation of Neutrophil Extracellular Traps.

Applications

Unspecified application

Species

Unspecified reactive species

Yuting Feng,Xue Bao,Jinxuan Zhao,Lina Kang,Xuan Sun,Biao Xu
View all publications
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