Anti-TRIOBP antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The TRIOBP protein also known as Trio-Binding Protein has a molecular mass of approximately 75 kDa though it may vary depending on the isoform. It localizes in various tissues with strong expression in the brain suggesting a role in neural processes. TRIOBP interacts with the actin cytoskeleton mainly influencing cell shape and movement. It is known for binding to Trio a guanine nucleotide exchange factor involved in actin rearrangement which highlights its importance in maintaining structural integrity at the cellular level.

Biological function summary

This protein influences cellular dynamics by maintaining cytoskeletal architecture. TRIOBP can exist in several isoforms implicated in different cellular processes. It interacts with signaling complexes typically playing roles in neuronal development and synaptic functioning. In the context of cellular networks TRIOBP's involvement in communication pathways between cells supports its significance in maintaining efficient cellular communication.

Pathways

TRIOBP integrates into regulatory systems impacting neuronal signaling and actin cytoskeleton reorganization. The protein operates within pathways including the Rho GTPase signaling where it connects with proteins like Filamin A to mediate cytoskeletal alterations. It is also associated with pathways influencing neuronal growth working alongside DLG family proteins pivotal in synaptic signaling and plasticity.

Associated diseases and disorders

Mutations or modifications in TRIOBP link to certain health conditions. It associates notably with schizophrenia where altered expression impacts neural connectivity. The protein also bears relevance to hearing loss interacting closely with DFNB28 gene products that affect inner ear hair cell function. Both conditions illustrate the protein's influence on nervous system integrity and sensory processing.