Anti-TRNT1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TRNT1 also known as tRNA nucleotidyl transferase 1 is a protein that attaches the CCA sequence to the 3' end of tRNA molecules. This addition is essential for transferring amino acids during protein synthesis. TRNT1 has a molecular mass of about 48 kDa. The protein is expressed in many tissues but is particularly abundant in metabolically active tissues like heart and liver where protein synthesis is high.

Biological function summary

The addition of the CCA tail is a necessary step at the end of tRNA maturation. Without this tRNA molecules cannot function in protein synthesis. TRNT1 does not work alone; it complements the function of other tRNA modifying enzymes adding the correct nucleotides to tRNA. TRNT1 frequently interacts with other molecules to ensure the processing is accurate and efficient.

Pathways

TRNA CCA addition by TRNT1 plays a role in RNA processing and protein synthesis pathways. These pathways are fundamental for cell function impacting how cells make proteins. TRNT1 interacts with other RNA-related proteins like tRNA synthetases which help link tRNA to specific amino acids. This interaction shows the connectedness of TRNT1 with proteins involved in translational machinery.

Associated diseases and disorders

Improper function of TRNT1 associates with sideroblastic anemia with B-cell immunodeficiency periodic fevers and developmental delay (SIFD). In this context inadequate TRNT1 activity leads to defective tRNA maturation contributing to disease symptoms. TRNT1’s malfunction can also relate to other proteins in these diseases such as mutant forms of certain mitochondrial proteins exacerbating clinical features.