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AB64320

Anti-TROP2 antibody

4

(3 Reviews)

|

(4 Publications)

Rabbit Polyclonal TROP2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TACSTD2.

View Alternative Names

GA733-1, M1S1, TROP2, TACSTD2, Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TROP2 antibody (AB64320)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TROP2 antibody (AB64320)

ICC/IF image of ab64320 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab64320) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43μM.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human TACSTD2. The exact immunogen used to generate this antibody is proprietary information.

P09758

Specificity

Reacts specifically with human 35 kDa TROP2 protein.

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB79976

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TROP2 also known as TACSTD2 or tumor-associated calcium signal transducer 2 is a single-pass type I membrane glycoprotein. This protein is about 35 kDa in mass and primarily expresses in epithelial tissues. It acts as a transmembrane receptor that plays a role in signal transduction due to its domain structure binding and activation processes on the cell surface. TROP2 exhibits high expression in several types of tumors making it a potential target for therapeutic antibodies like anti-TROP2 anti trop2 or anti-TROP-2.
Biological function summary

TROP2 mediates calcium signaling and cell proliferation. It functions by being a part of a signaling complex on the cell membrane which affects multiple cellular activities such as cell growth motility and survival. Its role in maintaining the integrity of the epithelial cell layer also shows TROP2's significance in normal tissue homeostasis. The interaction of TROP2 with the extracellular matrix and other cell surface proteins support the structural integrity and communication between cells.

Pathways

TROP2 plays a central role in the PI3K/AKT and MAPK signaling pathways that regulate cell growth and survival. Within these pathways TROP2 works in concert with proteins like ERK and AKT important for transmitting extracellular signals into appropriate cellular responses. These pathways are key regulators of many physiological processes including cell cycle progression and apoptosis prevention.

TROP2 is strongly associated with several types of cancers particularly epithelial cancers like breast and pancreatic cancer. Overexpression of TROP2 in tumors often correlates with poor prognosis and aggressive disease phenotypes. Interaction between TROP2 and proteins like EGFR in cancer cell signaling pathways amplifies tumor progression and metastasis. Understanding these associations makes TROP2 a significant target in developing therapeutic strategies for cancer treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May function as a growth factor receptor.
See full target information TACSTD2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Clinical proteomics 22:36 PubMed41062929

2025

Salivary small extracellular vesicles reveal protein signatures in young patients with coronary artery disease.

Applications

Unspecified application

Species

Unspecified reactive species

Pratibha Sharma,Meetanshi Sancheti,Krishna Kishore Inampudi,Ambuj Roy,Rajinder K Dhamija

Asian journal of pharmaceutical sciences 20:101039 PubMed40487121

2025

Multifunctional tri-layer wound dressing containing ZNO nanoparticles and IGF-1 as an efficient biomaterial for healing of full thickness skin injuries.

Applications

Unspecified application

Species

Unspecified reactive species

Azin Abedi Koupai,Jaleh Varshosaz,Mohamadreza Tavakoli,Marjan Mirhaj,Saeideh Salehi,Faramarz Dobakhti

Scientific reports 14:7683 PubMed38561502

2024

Differential cytokine expression in gastric tissues highlights helicobacter pylori's role in gastritis.

Applications

Unspecified application

Species

Unspecified reactive species

Xing-Tang Yang,Pei-Qin Niu,Xiao-Feng Li,Ming-Ming Sun,Wei Wei,Yan-Qing Chen,Jia-Yi Zheng

Antioxidants (Basel, Switzerland) 12: PubMed36978843

2023

Swietenine Alleviates Nonalcoholic Fatty Liver Disease in Diabetic Mice via Lipogenesis Inhibition and Antioxidant Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Kit-Kay Mak,Shiming Zhang,Jestin Chellian,Zulkefeli Mohd,Ola Epemolu,Albena T Dinkova-Kostova,Madhu Katyayani Balijepalli,Mallikarjuna Rao Pichika
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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