JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB230276

Anti-Tropomodulin 1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Tropomodulin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TMOD1.

View Alternative Names

D9S57E, TMOD, TMOD1, Tropomodulin-1, Erythrocyte tropomodulin, E-Tmod

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tropomodulin 1 antibody (AB230276)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tropomodulin 1 antibody (AB230276)

Paraffin-embedded human pancreatic tissue stained for Tropomodulin 1 using ab230276 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tropomodulin 1 antibody (AB230276)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tropomodulin 1 antibody (AB230276)

Paraffin-embedded human heart tissue stained for Tropomodulin 1 using ab230276 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TMOD1.

P28289

style
left-column

Alternative Products

Primary Antibodies

AB229679

Anti-Tropomodulin 1 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-Tropomodulin 1 antibody - C-terminal (AB229679)

  • 0
  • 0
Primary Antibodies

AB88608

Anti-Tropomodulin 1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Tropomodulin 1 antibody (AB88608)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB308011

Anti-MAP3K8/COT antibody [RP23040075]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-MAP3K8/COT antibody [RP23040075] (AB308011)

  • 0
  • 0
Primary Antibodies

AB186729

Anti-FANCB antibody [EPR15513]

RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FANCB antibody [EPR15513] (AB186729)

  • 2
  • 1
Primary Antibodies

AB68167

Anti-Sarcomeric Alpha Actinin antibody [EP2529Y]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody [EP2529Y] (AB68167)

  • 5
  • 9
Primary Antibodies

AB205618

Anti-MYOM1 antibody [EPR17322-9]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MYOM1 antibody [EPR17322-9] (AB205618)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tropomodulin 1 also known as TMOD1 is a capping protein responsible for regulating actin filament dynamics by binding to the pointed end of actin filaments preventing filament elongation and depolymerization. This interaction involves actin-binding sites and tropomyosin-binding regions providing stability to the filament structure. Tropomodulin 1 has an approximate mass of 40 kDa and is expressed in multiple tissues predominantly found in skeletal and cardiac muscles where it plays an essential role in maintaining the integrity of muscle fibers.
Biological function summary

Tropomodulin 1 controls the length of actin filaments impacting muscle contraction and cell motility. It forms part of a larger complex with tropomyosin assisting in stabilizing thin filaments. By effectively managing actin filament architecture Tropomodulin 1 contributes to structural cellular functions supporting cell morphology and intracellular transport. Its interaction with tropomyosin facilitates the proper functioning of contractile systems in muscle cells.

Pathways

Tropomodulin 1 participates in the sarcomere organization and muscle contraction pathways where it ensures the appropriate arrangement of the actin cytoskeleton. Tropomodulin 1’s regulation of actin-tropomyosin interactions affects proteins such as troponin which plays an important role in the regulation of calcium binding during muscle contractions. These pathways are critical for muscle development and proper neuromuscular functionality.

Mutations or dysregulation of Tropomodulin 1 have been implicated in cardiomyopathies and nemaline myopathy. These conditions often result from mismanagement of actin filament lengths affecting muscle fiber stability. Tropomodulin 1’s pathological role often involves disruptions in its binding with tropomyosin and such imbalances can lead to severe muscular disorders. By affecting the actin cytoskeleton Tropomodulin 1 connections to proteins such as actin and tropomyosin become significant in understanding these muscle-related diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed : 38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
See full target information TMOD1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC medical genomics 16:143 PubMed37344844

2023

A non-coding variant in the Kozak sequence of RARS2 strongly decreases protein levels and causes pontocerebellar hypoplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Romain Nicolle,Nami Altin,Karine Siquier-Pernet,Sherlina Salignac,Pierre Blanc,Arnold Munnich,Christine Bole-Feysot,Valérie Malan,Barthélémy Caron,Patrick Nitschké,Isabelle Desguerre,Nathalie Boddaert,Marlène Rio,Antonio Rausell,Vincent Cantagrel
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com