AB67407

Anti-Tropomodulin 2 antibody

Name: Anti-Tropomodulin 2 antibody (ab67407) | Abcam
Brand: Abcam Limited
SKU: AB67407
Price: 545 USD
Availability: InStock
Rating: 5 (3 reviews)

(3 Reviews)

(4 Publications)

Mouse Polyclonal Tropomodulin 2 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TMOD2.

View Alternative Names

NTMOD, TMOD2, Tropomodulin-2, Neuronal tropomodulin, N-Tmod

2 Images

AbReview34372****

Western blot - Anti-Tropomodulin 2 antibody (AB67407)

All lanes:

Western blot - Anti-Tropomodulin 2 antibody (ab67407) at 1/1000 dilution

All lanes:

N1E-115 mouse neuroblastoma at 20 µg

Secondary

All lanes:

Polyclonal HRP conjugate at 1/5000 dilution

Predicted band size: 40 kDa

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Western blot - Anti-Tropomodulin 2 antibody (AB67407)

All lanes:

Western blot - Anti-Tropomodulin 2 antibody (ab67407) at 1/500 dilution

Lane 1:

Tropomodulin 2 transfected 293T lysate at 25 µg

Lane 2:

Non transfected 293T lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 40 kDa

Observed band size: 39.6 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TMOD2.

Q9NZR1

Specificity

ab67407 is reactive against mammalian transfected lysate

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tropomodulin 2 also known as Tmod2 is a protein that regulates the actin cytoskeleton dynamics by capping the pointed end of actin filaments. It prevents the addition and loss of actin subunits at this end stabilizing the filament structure. With an approximate molecular weight of 40 kDa Tropomodulin 2 is expressed mainly in the brain but levels vary in different neural tissues. This protein shares functional similarities with Tropomodulin isoforms particularly in its role of filament capping.

Biological function summary

The Tropomodulin 2 protein plays an important role in maintaining neural tissue integrity by influencing actin filament stability which affects cellular structures and signaling. Its association with other Tropomodulin proteins such as Tmod1 and Tmod4 suggests a multi-protein complex role in actin filament control. This actin stabilization is vital for synaptic structure and neuronal growth which are critical processes for effective neurocommunication.

Pathways

Tropomodulin 2 is actively involved in cytoskeletal dynamics that are important for pathways like those in neurodevelopment and synaptic function. Within these pathways it interacts with proteins such as tropomyosin which also binds to actin and enhances filament stabilization. Tropomodulin 2's function in these pathways impacts cellular morphology and motility impacting overall neurological development and maintenance.

Abnormal expression or dysfunction of Tropomodulin 2 has been linked to neurological disorders including schizophrenia and neurodegenerative diseases. Variations in expression affect not only actin filament dynamics but also impact proteins like β-III spectrin which associates with the cytoskeleton abnormalities seen in these disorders. This connection highlights the importance of Tropomodulin 2 in maintaining normal neural function and how disruptions can lead to disease progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

See full target information TMOD2

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 38:10271-10285 PubMed30301754

2018

Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation.

Applications

Unspecified application

Species

Unspecified reactive species

Omotola F Omotade,Yanfang Rui,Wenliang Lei,Kuai Yu,H Criss Hartzell,Velia M Fowler,James Q Zheng

Nature communications 6:6789 PubMed25858512

2015

miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.

Applications

Unspecified application

Species

Unspecified reactive species

Qin-Hua Gu,Danni Yu,Zhonghua Hu,Xing Liu,Yanqin Yang,Yan Luo,Jun Zhu,Zheng Li

Nature communications 5:3263 PubMed24535612

2014

miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression.

Applications

ICC/IF, WB

Species

Unspecified reactive species, Unspecified reactive species

Zhonghua Hu,Danni Yu,Qin-hua Gu,Yanqin Yang,Kang Tu,Jun Zhu,Zheng Li

Journal of proteomics 74:547-57 PubMed21262400

2011

A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain.

Applications

Species

Human

Yanwei Sun,Mara Dierssen,Nuria Toran,Daniela D Pollak,Wei-Qiang Chen,Gert Lubec

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Tropomodulin 2 antibody

Western blot - Anti-Tropomodulin 2 antibody (AB67407)

Western blot - Anti-Tropomodulin 2 antibody (AB67407)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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