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AB155028

Anti-Troponin T1/TNT antibody

3

(1 Review)

|

(3 Publications)

Rabbit Polyclonal Troponin T1/TNT antibody. Suitable for IHC-P, WB and reacts with Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNNT1 aa 1 to C-terminus.

View Alternative Names

TNT, TNNT1, TnTs, Slow skeletal muscle troponin T, sTnT

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB155028)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB155028)

Immunohistochemical analysis of paraffin embedded Human colon carcinoma tissue, labeling Troponin T1/TNT using ab155028 at 1/500 dilution.

Western blot - Anti-Troponin T1/TNT antibody (AB155028)
  • WB

Unknown

Western blot - Anti-Troponin T1/TNT antibody (AB155028)

10% SDS PAGE

All lanes:

Western blot - Anti-Troponin T1/TNT antibody (ab155028) at 1/1000 dilution

All lanes:

H1299 whole cell lysate at 30 µg

Predicted band size: 33 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB155028)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB155028)

Immunohistochemical analysis of paraffin embedded Pig skeletal muscle tissue, labeling Troponin T1/TNT using ab155028 at 1/500 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TNNT1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P13805

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Alternative Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Pig": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Keep as concentrated solution.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Troponin T1 also known as TNT or skeletal muscle Troponin T is an important player in muscle contraction. This protein interacts with actin and tropomyosin to regulate the calcium-mediated contraction process. Troponin T1 has a molecular mass of approximately 36 kDa. It is strongly expressed in skeletal and cardiac muscles. This protein provides critical structural roles linking the components of the troponin complex together which in turn influences muscle contraction efficiency.
Biological function summary

This protein is a component of the troponin complex which also includes the proteins Troponin I and Troponin C. Troponin T1 binds tropomyosin and helps to align the troponin complex along the actin filament. This alignment is needed for the regulation of actin-myosin crossbridge formation. Through these interactions Troponin T1 allows skeletal and cardiac muscles to respond to calcium concentration changes during contraction.

Pathways

Troponin T1 participates mainly in the calcium signaling pathway and plays an important role in muscle contraction pathways. Its interaction with Troponin C affects calcium binding dynamics which is important for muscle contraction cycles. This coordination with Troponin I helps inhibit ATPase activity based on calcium presence ensuring efficient muscle relaxation following contraction.

Mutations in the Troponin T1 gene are linked to skeletal muscle diseases like nemaline myopathy. This condition affects muscle tone and strength mostly impacting infants and children. Troponin mutations also connect to hypertrophic cardiomyopathy a disorder that thickens the heart muscle potentially leading to heart failure. Mutations in genes encoding these proteins can disrupt normal muscle contraction cycles leading to these serious health issues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
See full target information TNNT1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cellular oncology (Dordrecht, Netherlands) 48:815-834 PubMed40327295

2025

High extracellular matrix stiffness upregulates TNNT1 to awaken dormant tumor cells in liver metastatic niches of gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Linhua Ji,Jie Peng,Yuxuan Lin,Yiqing Zhong,Bo Ni,Chunchao Zhu,Zizhen Zhang

iScience 28:111626 PubMed39850359

2025

Alternative splicing of EZH2 regulated by SNRPB mediates hepatocellular carcinoma progression via BMP2 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xingyu Wang,Weiyi Liu,Chunai Zhan,Yuanyuan Zhang,Xinyu Li,Yaoyun Wang,Mengfei Sheng,Madiha Maqsood,Hang Shen,Anmin Liang,Wei Shao

Proteomics 16:2028-42 PubMed27246553

2016

Quantitative proteome profiling of dystrophic dog skeletal muscle reveals a stabilized muscular architecture and protection against oxidative stress after systemic delivery of MuStem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Aurélie Lardenois,Sabrina Jagot,Mélanie Lagarrigue,Blandine Guével,Mireille Ledevin,Thibaut Larcher,Laurence Dubreil,Charles Pineau,Karl Rouger,Laëtitia Guével
View all publications
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Product promise

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