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AB193546

Anti-Troponin T1/TNT antibody

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(2 Publications)

Rabbit Polyclonal Troponin T1/TNT antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TNNT1 aa 150-250.

View Alternative Names

TNT, TNNT1, TnTs, Slow skeletal muscle troponin T, sTnT

1 Images
Western blot - Anti-Troponin T1/TNT antibody (AB193546)
  • WB

Supplier Data

Western blot - Anti-Troponin T1/TNT antibody (AB193546)

All lanes:

Western blot - Anti-Troponin T1/TNT antibody (ab193546)

Lane 1:

A549 whole cell lysate

Lane 2:

sp2/0 whole cell lysate

Lane 3:

Rat skeletal muscle tissue lysate

Predicted band size: 33 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TNNT1 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

P13805

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab193546 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Troponin T1 also known as TNT or skeletal muscle Troponin T is an important player in muscle contraction. This protein interacts with actin and tropomyosin to regulate the calcium-mediated contraction process. Troponin T1 has a molecular mass of approximately 36 kDa. It is strongly expressed in skeletal and cardiac muscles. This protein provides critical structural roles linking the components of the troponin complex together which in turn influences muscle contraction efficiency.
Biological function summary

This protein is a component of the troponin complex which also includes the proteins Troponin I and Troponin C. Troponin T1 binds tropomyosin and helps to align the troponin complex along the actin filament. This alignment is needed for the regulation of actin-myosin crossbridge formation. Through these interactions Troponin T1 allows skeletal and cardiac muscles to respond to calcium concentration changes during contraction.

Pathways

Troponin T1 participates mainly in the calcium signaling pathway and plays an important role in muscle contraction pathways. Its interaction with Troponin C affects calcium binding dynamics which is important for muscle contraction cycles. This coordination with Troponin I helps inhibit ATPase activity based on calcium presence ensuring efficient muscle relaxation following contraction.

Mutations in the Troponin T1 gene are linked to skeletal muscle diseases like nemaline myopathy. This condition affects muscle tone and strength mostly impacting infants and children. Troponin mutations also connect to hypertrophic cardiomyopathy a disorder that thickens the heart muscle potentially leading to heart failure. Mutations in genes encoding these proteins can disrupt normal muscle contraction cycles leading to these serious health issues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
See full target information TNNT1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

European journal of histochemistry : EJH 68: PubMed38686889

2024

Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Chaojie He,Yi Yu,Feifan Wang,Wudi Li,Hui Ni,Meixiang Xiang

Microbiome 11:41 PubMed36869365

2023

Maternal effects drive intestinal development beginning in the embryonic period on the basis of maternal immune and microbial transfer in chickens.

Applications

Unspecified application

Species

Unspecified reactive species

Haizhou Gong,Taiping Wang,Min Wu,Qianran Chu,Hainan Lan,Wuying Lang,Lingyu Zhu,Yang Song,Yujie Zhou,Qiongyi Wen,Jing Yu,Baolin Wang,Xin Zheng
View all publications
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