Anti-Troponin T1/TNT antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Troponin T1 also known as TNT or skeletal muscle Troponin T is an important player in muscle contraction. This protein interacts with actin and tropomyosin to regulate the calcium-mediated contraction process. Troponin T1 has a molecular mass of approximately 36 kDa. It is strongly expressed in skeletal and cardiac muscles. This protein provides critical structural roles linking the components of the troponin complex together which in turn influences muscle contraction efficiency.

Biological function summary

This protein is a component of the troponin complex which also includes the proteins Troponin I and Troponin C. Troponin T1 binds tropomyosin and helps to align the troponin complex along the actin filament. This alignment is needed for the regulation of actin-myosin crossbridge formation. Through these interactions Troponin T1 allows skeletal and cardiac muscles to respond to calcium concentration changes during contraction.

Pathways

Troponin T1 participates mainly in the calcium signaling pathway and plays an important role in muscle contraction pathways. Its interaction with Troponin C affects calcium binding dynamics which is important for muscle contraction cycles. This coordination with Troponin I helps inhibit ATPase activity based on calcium presence ensuring efficient muscle relaxation following contraction.

Associated diseases and disorders

Mutations in the Troponin T1 gene are linked to skeletal muscle diseases like nemaline myopathy. This condition affects muscle tone and strength mostly impacting infants and children. Troponin mutations also connect to hypertrophic cardiomyopathy a disorder that thickens the heart muscle potentially leading to heart failure. Mutations in genes encoding these proteins can disrupt normal muscle contraction cycles leading to these serious health issues.