Anti-TROY antibody [EPR3214(2)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The TROY protein also known as TNFRSF19 is a member of the tumor necrosis factor receptor superfamily. It has a molecular mass of approximately 42 kDa. TROY is mainly expressed in the central nervous system particularly in brain tissue but researchers also detect it in certain peripheral tissues. The protein contains an extracellular domain a single transmembrane segment and a cytoplasmic domain that interacts with other intracellular signaling proteins. These structural components allow it to function effectively in signal transduction throughout the cells.

Biological function summary

TROY protein plays a significant role in the central nervous system's development and maintenance. It interacts with components of the neurotrophin signaling pathway including p75 neurotrophin receptor to influence neuronal survival and differentiation. TROY does not function alone; it is part of receptor complexes that modulate various intracellular pathways. Its interactions with ligands like Nogo receptor and LINGO-1 indicate its involvement in restricting neuronal growth impacting axon regeneration and central nervous system repair processes.

Pathways

The TROY protein integrates into neurotrophin signaling and axon guidance pathways. In neurotrophin signaling it affects cellular response to growth factors essential for neural growth and survival. In axon guidance TROY impacts cellular navigation cues that direct axon growth. This protein interacts closely with other molecules such as the Nogo receptor which often collaborates in signaling cascades that influence these pathways. These interactions underline TROY's contribution to maintaining the delicate balance of neuronal connections.

Associated diseases and disorders

TROY protein has links to neurodegenerative disorders like Alzheimer's disease and multiple sclerosis. Alzheimer's disease research shows that TROY might influence amyloid-beta peptide interactions exacerbating neuronal degradation processes. Similarly in multiple sclerosis the protein's role in inhibiting axon regrowth makes it a potential target for therapeutic intervention. TROY's interaction with proteins such as p75 and Nogo receptor highlights its influence on disease progression by mediating cellular processes that relate to neurodegeneration and neuron damage response.