AB93618

Anti-TRP 7 antibody [N64A/36]

Name: Anti-TRP 7 antibody [N64A/36] (ab93618) | Abcam
Brand: Abcam Limited
SKU: AB93618
Price: 510 USD
Availability: InStock

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(2 Publications)

Mouse Monoclonal TRP 7 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TRPC7 aa 850 to C-terminus.

View Alternative Names

TRP7, TRPC7, Short transient receptor potential channel 7, TrpC7, Transient receptor protein 7, TRP-7, hTRP7

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-TRP 7 antibody [N64A/36] (AB93618)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TRP 7 antibody [N64A/36] (AB93618)

Cold 100% methanol for 10 minutes at -20°C fixed HaCaT cells labeling TRP 7 (green) using ab93618 at 1/100 dilution for 1 hour at room temperature. FITC Goat anti-mouse (green) was used as the secondary antibody at 1/50 dilution for 1 hour at room temperature. Nuclear staining is observed.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRP 7 antibody [N64A/36] (AB93618)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRP 7 antibody [N64A/36] (AB93618)

Bouin's-fixed, paraffin-embedded mouse backskin tissue stained for TRP 7 (green) using ab93618 at 1/100 dilution in immunohistochemical analysis. Goat Anti-Mouse was used as the secodary antibody at 1/50 dilution.

Unknown

Western blot - Anti-TRP 7 antibody [N64A/36] (AB93618)

Western blot detection of Trp7 in Rat brain membrane lysates using ab93618 at 1 : 1000 dilution.

All lanes:

Western blot - Anti-TRP 7 antibody [N64A/36] (ab93618)

Predicted band size: 100 kDa

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Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

N64A/36

Isotype

IgG1

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human TRPC7 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9HCX4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-10 µg/mL", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.1-1 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-10 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

The clone number has been updated from S64A-36 to N64A/36, both clone numbers name the same antibody clone.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRP 7 also known as Transient Receptor Potential Channel 7 is a mechanically gated ion channel of the TRP family. It has a molecular mass of approximately 90 kDa. You find TRP 7 predominantly in tissues like the brain and heart where it participates in calcium signaling. It functions as a receptor that allows ions to flow across the cell membrane in response to mechanical stress or temperature changes modulating cellular excitability and signal transduction.

Biological function summary

This protein plays a critical role in the regulation of calcium ion concentrations within the cell. TRP 7 often integrates into larger protein complexes that aid in cellular response to environmental stimuli. These complexes impact processes like muscle contraction nerve transmission and hormone secretion. Its function in maintaining ion balance makes it integral to both physiological stability and adaptive processes.

Pathways

TRP 7 integrates into calcium signaling pathways where it interacts with proteins such as calmodulin and protein kinase. This protein is also part of the mechanotransduction pathway impacting how cells react to mechanical forces. TRP 7 has associations with other TRP family members contributing to its broad regulatory roles in cellular homeostasis and adaptation.

Research indicates TRP 7 associates with cardiomyopathy and neuropathic pain. Changes in its expression or function can lead to abnormal calcium signaling contributing to these conditions. In cardiomyopathy its interaction with proteins like calcineurin affects cardiac function while in neuropathic pain changes in TRP 7 can alter nerve sensitivity and pain perception pathways. Understanding TRP 7's role provides insights into potential therapeutic targets for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.

See full target information TRPC7

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 49:439-446 PubMed32985156

2020

[Correlation between transient receptor potential canonical channel with heart and kidney injure of rat model of obstructive sleep apnea hypopnea syndrome].

Applications

Unspecified application

Species

Unspecified reactive species

Wen Wen,Qiaoling Yao,Yulan Chen,Zhiqiang Li,Xiaojing Sun,Yu Li,Junshi Zhang,Zhulipiya Simayi,Xinjuan Xu

PloS one 12:e0177469 PubMed28531217

2017

Store-operated Ca2+ entry supports contractile function in hearts of hibernators.

Applications

Unspecified application

Species

Unspecified reactive species

Olga V Nakipova,Alexey S Averin,Edward V Evdokimovskii,Oleg Yu Pimenov,Leonid Kosarski,Dmitriy Ignat'ev,Andrey Anufriev,Yuri M Kokoz,Santiago Reyes,Andre Terzic,Alexey E Alekseev

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TRP 7 antibody [N64A/36]

Immunocytochemistry/ Immunofluorescence - Anti-TRP 7 antibody [N64A/36] (AB93618)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRP 7 antibody [N64A/36] (AB93618)

Western blot - Anti-TRP 7 antibody [N64A/36] (AB93618)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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