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AB110837

Anti-TRPC1 antibody

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(4 Publications)

Goat Polyclonal TRPC1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TRPC1 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

TRP1, TRPC1, Short transient receptor potential channel 1, TrpC1, Transient receptor protein 1, TRP-1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPC1 antibody (AB110837)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPC1 antibody (AB110837)

ab110837 at 3.75 μg/ml staining TRPC1 in Human cortex by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPC1 antibody (AB110837)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPC1 antibody (AB110837)

ab110837 at 3.75 µg/ml staining TRPC1 in Human Prostate (fibromuscular stroma) by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TRPC1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P48995

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRPC1 also known as the Transient Receptor Potential Channel 1 is a protein that forms ion channels in cell membranes facilitating the movement of calcium ions into cells. TRPC1 has a molecular mass of approximately 89 kDa. It is mainly expressed in the central nervous system such as the brain as well as in tissues like the heart lungs and skeletal muscles. TRPC1 operates as a non-selective cation channel that responds to a variety of stimuli including mechanical thermal and chemical signals.
Biological function summary

TRPC1 plays roles in various cellular functions including cell growth muscle contraction and ion homeostasis. TRPC1 often associates with other TRP channel proteins forming heteromeric complexes that modify its channel properties. Through these complexes TRPC1 contributes to regulating intracellular calcium levels which are important for numerous physiological processes. Its role in maintaining calcium balance highlights its importance in cellular signalling and functional regulation in many cell types.

Pathways

Researchers identify TRPC1 as an essential component of the calcium signalling pathway influencing cellular activities like proliferation and apoptosis. TRPC1 also integrates within the phosphoinositide signalling pathway where it interacts with proteins such as STIM1 and Orai1. These interactions facilitate the entry of calcium ions into the cells important in conditions of calcium store depletion and cellular signalling cascades.

TRPC1 is implicated in cardiovascular diseases and neurodegenerative disorders. Dysregulation of TRPC1 activity leads to altered calcium homoeostasis contributing to the development and progression of conditions like hypertension and Alzheimer's disease. In Alzheimer's interactions between TRPC1 and amyloid precursor protein (APP) may influence neuronal function and survival showcasing its potential as a therapeutic target for research and drug development in these life-impacting conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Also activated by intracellular calcium store depletion.. Isoform Short. Forms a receptor-activated non-selective calcium permeant cation channel. Also activated by intracellular calcium store depletion.
See full target information TRPC1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The Tohoku journal of experimental medicine 264:141-149 PubMed38925952

2024

The Prognostic Significance of Transient Receptor Potential Canonical 1 and Its Association with Vascular Endothelial Growth Factor Receptor 2 in Papillary Thyroid Carcinoma Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Mengshi Chen,Bo Liu,Zhaoming Ding,Ruinan Sheng,Jiewu Zhang

World journal of gastrointestinal oncology 15:2064-2076 PubMed38173438

2024

Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Cai Mei,Qian Chen,Shi Zuo

EMBO molecular medicine 14:e14485 PubMed34826211

2021

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Wang,Cun Li,Man Chun Chiu,Yifei Yu,Xiaojuan Liu,Xiaoyu Zhao,Jingjing Huang,Zhongshan Cheng,Shuofeng Yuan,Vincent Poon,Jian-Piao Cai,Hin Chu,Jasper Fuk-Woo Chan,Kelvin Kai-Wang To,Kwok Yung Yuen,Jie Zhou

Frontiers in oncology 11:627713 PubMed33854967

2021

TRPC1 Inhibits Cell Proliferation/Invasion and Is Predictive of a Better Prognosis of Esophageal Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Zhu Zeng,Yong-Qu Zhang,Jiong-Yu Chen,Li-Ying Zhang,Wen-Liang Gao,Xue-Qiong Lin,Shao-Min Huang,Fan Zhang,Xiao-Long Wei
View all publications
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