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AB192031

Anti-TRPC1 antibody [EPR1417(2)]

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(9 Publications)

Rabbit Recombinant Monoclonal TRPC1 antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 9 publications.

View Alternative Names

TRP1, TRPC1, Short transient receptor potential channel 1, TrpC1, Transient receptor protein 1, TRP-1

2 Images
Western blot - Anti-TRPC1 antibody [EPR1417(2)] (AB192031)
  • WB

Supplier Data

Western blot - Anti-TRPC1 antibody [EPR1417(2)] (AB192031)

All lanes:

Western blot - Anti-TRPC1 antibody [EPR1417(2)] (ab192031) at 1/10000 dilution

Lane 1:

SH-SY5Y lysate at 20 µg

Lane 2:

HepG2 lysate at 20 µg

Lane 3:

Caco-2 lysate at 20 µg

Lane 4:

Human testis lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 91 kDa

Observed band size: 120 kDa

false

Western blot - Anti-TRPC1 antibody [EPR1417(2)] (AB192031)
  • WB

Supplier Data

Western blot - Anti-TRPC1 antibody [EPR1417(2)] (AB192031)

All lanes:

Western blot - Anti-TRPC1 antibody [EPR1417(2)] (ab192031) at 1/1000 dilution

Lane 1:

Mouse brain lysate at 10 µg

Lane 2:

Rat brain lysate at 10 µg

Lane 3:

PC-12 lysate at 10 µg

Lane 4:

NIH3T3 lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 91 kDa

Observed band size: 120 kDa

false

  • Carrier free

    Anti-TRPC1 antibody [EPR1417(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR1417(2)

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRPC1 also known as the Transient Receptor Potential Channel 1 is a protein that forms ion channels in cell membranes facilitating the movement of calcium ions into cells. TRPC1 has a molecular mass of approximately 89 kDa. It is mainly expressed in the central nervous system such as the brain as well as in tissues like the heart lungs and skeletal muscles. TRPC1 operates as a non-selective cation channel that responds to a variety of stimuli including mechanical thermal and chemical signals.
Biological function summary

TRPC1 plays roles in various cellular functions including cell growth muscle contraction and ion homeostasis. TRPC1 often associates with other TRP channel proteins forming heteromeric complexes that modify its channel properties. Through these complexes TRPC1 contributes to regulating intracellular calcium levels which are important for numerous physiological processes. Its role in maintaining calcium balance highlights its importance in cellular signalling and functional regulation in many cell types.

Pathways

Researchers identify TRPC1 as an essential component of the calcium signalling pathway influencing cellular activities like proliferation and apoptosis. TRPC1 also integrates within the phosphoinositide signalling pathway where it interacts with proteins such as STIM1 and Orai1. These interactions facilitate the entry of calcium ions into the cells important in conditions of calcium store depletion and cellular signalling cascades.

TRPC1 is implicated in cardiovascular diseases and neurodegenerative disorders. Dysregulation of TRPC1 activity leads to altered calcium homoeostasis contributing to the development and progression of conditions like hypertension and Alzheimer's disease. In Alzheimer's interactions between TRPC1 and amyloid precursor protein (APP) may influence neuronal function and survival showcasing its potential as a therapeutic target for research and drug development in these life-impacting conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Also activated by intracellular calcium store depletion.. Isoform Short. Forms a receptor-activated non-selective calcium permeant cation channel. Also activated by intracellular calcium store depletion.
See full target information TRPC1
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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113085 PubMed40777047

2025

Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice.

Applications

Unspecified application

Species

Unspecified reactive species

Farah Issa,Xavier Yerna,Thibaud Parpaite,Caren Jabbour,Olivier Schakman,Nicolas Tajeddine,Roberta Gualdani,Philippe Gailly

Open medicine (Warsaw, Poland) 19:20241044 PubMed39381430

2024

Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin.

Applications

Unspecified application

Species

Unspecified reactive species

Enqi Zhao,Jinyu Wang,Yuefu Zhao,Qingqing Xia,Hongmai Wang,Zhanqiang Li,Cen Li,Xiangyun Gai

JCI insight 9: PubMed38564291

2024

Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice.

Applications

Unspecified application

Species

Unspecified reactive species

Satvik Mareedu,Nadezhda Fefelova,Cristi L Galindo,Goutham Prakash,Risa Mukai,Junichi Sadoshima,Lai-Hua Xie,Gopal J Babu

Hereditas 161:7 PubMed38297377

2024

Integrative single-cell analysis: dissecting CD8 + memory cell roles in LUAD and COVID-19 via eQTLs and Mendelian Randomization.

Applications

Unspecified application

Species

Unspecified reactive species

Jintao Wu,Xiaocheng Mao,Xiaohua Liu,Junying Mao,Xianxin Yang,Xiangwu Zhou,Lu Tianzhu,Yulong Ji,Zhao Li,Huijuan Xu

NPJ Regenerative medicine 6:67 PubMed34671058

2021

Differential activation of Ca influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Naseem Ahamad,Yuyang Sun,Viviane Nascimento Da Conceicao,Caroline R D Xavier Paul Ezhilan,Mohan Natarajan,Brij B Singh

International journal of molecular sciences 19: PubMed30340421

2018

Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat Ex-Vivo Heart Model.

Applications

Unspecified application

Species

Unspecified reactive species

Amin Al-Awar,Nikoletta Almási,Renáta Szabó,Istvan Takacs,Zsolt Murlasits,Gergő Szűcs,Szilvia Török,Anikó Pósa,Csaba Varga,Krisztina Kupai

iScience 8:85-102 PubMed30293012

2018

M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry.

Applications

Unspecified application

Species

Unspecified reactive species

Arun Chauhan,Yuyang Sun,Pramod Sukumaran,Fredice O Quenum Zangbede,Christopher N Jondle,Atul Sharma,Dustin L Evans,Pooja Chauhan,Randolph E Szlabick,Mary O Aaland,Lutz Birnbaumer,Jyotika Sharma,Brij B Singh,Bibhuti B Mishra

Food & nutrition research 62: PubMed30083085

2018

Inhibitory effects of quail egg on mast cells degranulation by suppressing PAR2-mediated MAPK and NF-kB activation.

Applications

Unspecified application

Species

Unspecified reactive species

Priscilia Lianto,Fredrick O Ogutu,Yani Zhang,Feng He,Huilian Che

Scientific reports 7:7222 PubMed28775294

2017

Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shiwen Han,Lu Sun,Feng He,Huilian Che
View all publications
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