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Rabbit Polyclonal TRPC4AP antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TRPC4AP aa 50-300.

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Images

Western blot - Anti-TRPC4AP antibody (AB153810), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human TRPC4AP aa 50-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TEL6

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Predicted
Rat
Predicted
Cow
Predicted

Tested
Tested

Species
Human
Dilution info
1/500.00000 - 1/3000.00000
Notes

-

Predicted
Predicted

Species
Mouse, Rat, Cow
Dilution info
-
Notes

-

Target data

Function

Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948). The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948). The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (By similarity).

Alternative names

C20orf188, TRRP4AP, TRPC4AP, Short transient receptor potential channel 4-associated protein, Trp4-associated protein, Trpc4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS

Recommended products

Rabbit Polyclonal TRPC4AP antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TRPC4AP aa 50-300.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human TRPC4AP aa 50-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TEL6
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

TRPC4AP also known as TRPC4-associated protein acts mechanically as an adaptor protein that interacts with the TRPC4 ion channel. It plays a role in the regulation of calcium influx through this channel. With a molecular weight of approximately 76 kDa TRPC4AP has expression in various tissues including the brain and heart. Its interaction with TRPC4 affects cellular responses to calcium signals important for various cellular processes.

Biological function summary

TRPC4AP assists in anchoring TRPC4 channels to other signaling proteins impacting calcium-dependent signaling pathways. It often forms part of a multiprotein complex that modulates the activity and localization of these channels. This coordination affects cellular calcium homeostasis and influences processes such as muscle contraction neuronal signaling and endothelial barrier function.

Pathways

TRPC4AP contributes to processes like the phosphatidylinositol signaling system involving calcium release. It associates with proteins like calmodulin and IP3 receptors in this pathway. Additionally TRPC4AP plays a role in the calcium-dependent protein kinase (CaMK) pathway where it interacts with proteins critical for phosphorylation events controlled by calcium signaling.

Associated diseases and disorders

TRPC4AP has relevance in cardiovascular diseases and neurological disorders. Its disruption can lead to altered calcium signaling contributing to conditions such as heart failure and certain neurodegenerative diseases. TRPC4AP interacts with proteins linked to these conditions such as calcium-binding proteins and other signaling molecules involved in the affected pathways.

Product promise

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1 product image

  • Western blot - Anti-TRPC4AP antibody (ab153810), expandable thumbnail

    Western blot - Anti-TRPC4AP antibody (ab153810)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-TRPC4AP antibody (ab153810) at 1/1000 dilution

    All lanes: A549 whole cell lysate at 30 µg

    Predicted band size: 91 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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