Rabbit Polyclonal TRPM4 antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Mouse Trpm4.
Constituents: Whole serum
| WB | IHC-P | IHC-Fr | |
|---|---|---|---|
| Mouse | Expected | Expected | Expected |
| Rat | Predicted | Predicted | Predicted |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
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Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:17188667, PubMed:29211714). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells (PubMed:18758465). Plays a role in keratinocyte differentiation (By similarity) (PubMed:18758465). Isoform 3. Lacks channel activity.
Ltrpc4, Trpm4, Transient receptor potential cation channel subfamily M member 4, Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4
Rabbit Polyclonal TRPM4 antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Mouse Trpm4.
Constituents: Whole serum
TRPM4 also known as Transient Receptor Potential Melastatin 4 is a calcium-activated non-selective cation channel with a mass of approximately 138 kilodaltons. This protein allows the movement of monovalent cations such as sodium across the plasma membrane leading to membrane depolarization. TRPM4 expresses in numerous human tissues including the heart brain and immune cells. Researchers often study this channel to understand its role in cellular electric activities.
TRPM4 plays an important part in regulating membrane potential and cellular excitability. It does not function as part of a larger structural complex but its activity modulates various cellular processes. For instance it is important in cardiac conduction influencing heart rhythm by affecting the action potential duration. In immune cells TRPM4 contributes to cytokine release and cell movement impacting the body’s inflammatory response.
TRPM4's mechanism integrates into significant signaling pathways like the calcium signaling pathway and the cardiac conduction system. Within these pathways its function influences several key proteins. In the calcium signaling pathway TRPM4's activity can affect the function of calmodulin an important calcium sensor while in cardiac cells TRPM4 regulates voltage-gated calcium channels important for heart muscle contraction.
TRPM4’s roles associate it with conditions like cardiac arrhythmias and multiple sclerosis. In heart diseases TRPM4 interacts with proteins such as Na+/Ca2+ exchangers and abnormalities in this interaction can lead to arrhythmogenic conditions. For multiple sclerosis studies suggest that altered TRPM4 activity in immune cells impacts the immune response potentially linking it to the disease's progression. Understanding these interactions can provide insights for therapeutic targets.
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