Rabbit Polyclonal TRPV1 antibody. Suitable for IHC-FoFr and reacts with Rat samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Rat Trpv1 aa 1-50.
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Publications
- International journal of molecular sciences 23:2022Anti-Inflammatory Effect of Beta-Caryophyllene Mediated by the Involvement of TRPV1, BDNF and trkB in the Rat Cerebral Cortex after Hypoperfusion/Reperfusion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria Pina Serra,Marianna Boi,Antonella Carta,Elisabetta Murru,Gianfranca Carta,Sebastiano Banni,Marina QuartuPubMed 35408995
- Frontiers in pharmacology 11:6091192021Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLinjie Ju,Peipei Hu,Ping Chen,Jiejie Wu,Zhuoqun Li,Zhixia Qiu,Jun Cheng,Fang HuangPubMed 33574755
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: Whole serum- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Rat Trpv1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link O35433
Reactivity data
Select an application| IHC-FoFr | |
|---|---|
| Mouse | Predicted |
| Rat | Tested |
| Primates | Predicted |
IHC-FoFr
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/50 - 1/1000 | Notes (see Guo et al reference). |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Primates | Dilution info - | Notes - |
Associated Products
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Target data
Function
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.Isoform 3Does not display channel activity in response to noxious chemical compounds, such as capsaicin and the vanilloid resiniferatoxin. Channel activity is not elicited by mildly acidic extracellular pH, and only slight channel activity is observed in response to noxiuos heat stimuli.
Alternative names
Transient receptor potential cation channel subfamily V member 1, TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, Vanilloid receptor 1, Vanilloid receptor type 1-like, OTRPC1, Vr1l, Vr1, Trpv1
Recommended products
Rabbit Polyclonal TRPV1 antibody. Suitable for IHC-FoFr and reacts with Rat samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Rat Trpv1 aa 1-50.
Alternative names
Transient receptor potential cation channel subfamily V member 1, TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, Vanilloid receptor 1, Vanilloid receptor type 1-like, OTRPC1, Vr1l, Vr1, Trpv1
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: Whole serum- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Rat Trpv1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link O35433
- Purity
Whole antiserum
- Specificity
This antibody has been optimised on rat tissue. We recommend ab31895 for detection of TRPV1 in mouse tissue.
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
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Supplementary info
- Activity summary
TRPV1 also known as the transient receptor potential vanilloid 1 or capsaicin receptor is a non-selective cation channel with a molecular mass of approximately 95 kDa. It acts mechanically by allowing the influx of calcium and sodium ions upon activation. This receptor is expressed predominantly in sensory neurons specifically in dorsal root ganglia and trigeminal ganglia which are key regions involved in pain perception. TRPV1 can also be found in various non-neuronal tissues influencing a range of physiological responses.
- Biological function summary
The role of TRPV1 extends beyond sensory perception. It is involved in detecting and regulating body temperature and is activated by heat acidic conditions and certain lipid metabolites. The receptor operates as part of a homotetrameric complex contributing to neural signaling. It is activated by chemical ligands such as capsaicin the compound responsible for the spicy sensation in chili peppers influencing pain and inflammation pathways.
- Pathways
TRPV1 plays essential roles in pain and nociception pathways. It intersects with the inflammatory pathway where its activity is modulated by protein kinase C (PKC) and phospholipase C (PLC). These pathways involve calcium signaling and relate to proteins such as PKA and calcineurin which modulate TRPV1 activity through phosphorylation and dephosphorylation affecting the body's response to noxious stimuli.
- Associated diseases and disorders
TRPV1 is a critical player in pain management and inflammatory disorders. It has been linked to chronic pain conditions like neuropathic pain and is also involved in migraine pathophysiology. In these contexts TRPV1 interacts with proteins like CGRP and TRPA1 which are also implicated in pain signaling and migraine mechanisms. Antagonists such as capsazepine AMG 9810 and AMG-517 have been researched for therapeutic targeting of TRPV1 in these disorders.
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Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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1 product image
Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-TRPV1 antibody (ab10296)
Immunohistochemical analysis of rat dorsal root ganglion labeling TRPV1 with ab10296 at 1/50 dilution.
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