Rabbit Polyclonal TRPV2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRPV2 aa 1-150.
View Alternative Names
VRL, TRPV2, Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, Vanilloid receptor-like protein 1, OTRPC2, VRL-1
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV2 antibody (AB236955)
Paraffin-embedded human prostate tissue stained for TRPV2 using ab236955 at 1/800 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using a HRP conjugated SP system.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-TRPV2 antibody (AB236955)
HepG2 (Human liver hepatocellular carcinoma cell line) cells stained for TRPV2 (green) using ab236955 at 1/266 dilution in ICC/IF, followed by an Alexa-Fluor®488-conjugated goat anti-rabbit IgG (H+L). Counterstained with DAPI (blue).
The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal goat serum. The cells were then incubated with primary antibody overnight at 4°C.
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Supplementary information
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Biological function summary
TRPV2 acts as a sensor within cells and is vital for regulating calcium homeostasis affecting cellular responses in many types of cells. TRPV2 is not part of any multi-subunit complex but is often found located on the cell membrane where it modulates membrane potential and intracellular signaling. This protein contributes to tracking endogenous lipids for cellular signaling pathways necessary for various biological processes like muscle contraction and immune response.
Pathways
TRPV2 engages in cellular signaling pathways that modulate physiological responses. In particular it is part of the mechanotransduction and thermal sensing pathways where it interacts with proteins such as TRPV1 TRPV3 and TRPV4. These pathways are important for interpreting and reacting to mechanical and thermal stimuli influencing processes like inflammation and pain perception.
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Publications (1)
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Oncology reports 41:3347-3354 PubMed31002350
2019
Applications
Unspecified application
Species
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