AB272862

Anti-TRPV2 antibody

Name: Anti-TRPV2 antibody (ab272862) | Abcam
Brand: Abcam Limited
SKU: AB272862

Be the first to review this product! Submit a review

(2 Publications)

Rabbit Polyclonal TRPV2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRPV2.

View Alternative Names

VRL, TRPV2, Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, Vanilloid receptor-like protein 1, OTRPC2, VRL-1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV2 antibody (AB272862)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV2 antibody (AB272862)

Paraffin-embedded human lung tissue stained for TRPV2 using ab272862 at 10 μg/mL in immunohistochemical analysis. Antigen retrieval using EDTA based, pH 8.0 buffer, 15 minutes.

Supplier Data

Western blot - Anti-TRPV2 antibody (AB272862)

WCE : whole cell extract; ME : membrane extract.

A 5% gel was used to observe the high molecular weight protein and run until the 72 kDa marker reaches the bottom of the gel.

All lanes:

Western blot - Anti-TRPV2 antibody (ab272862) at 1/500 dilution

Lane 1:

K562 whole cell extracts at 30 µg

Lane 2:

K562 membrane extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 85.9 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TRPV2. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5S1

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRPV2 also known as transient receptor potential cation channel subfamily V member 2 is a non-selective cation channel with a molecular mass of around 85 kDa. Known for being heat-activated TRPV2 is sensitive to temperatures above 52°C. The protein is expressed in various tissues including heart lung spleen and brain. In neuronal and non-neuronal cells TRPV2 plays a role in calcium influx responding to potential mechanical stretch stimuli and cannabinoids like cannabidiol.

Biological function summary

TRPV2 acts as a sensor within cells and is vital for regulating calcium homeostasis affecting cellular responses in many types of cells. TRPV2 is not part of any multi-subunit complex but is often found located on the cell membrane where it modulates membrane potential and intracellular signaling. This protein contributes to tracking endogenous lipids for cellular signaling pathways necessary for various biological processes like muscle contraction and immune response.

Pathways

TRPV2 engages in cellular signaling pathways that modulate physiological responses. In particular it is part of the mechanotransduction and thermal sensing pathways where it interacts with proteins such as TRPV1 TRPV3 and TRPV4. These pathways are important for interpreting and reacting to mechanical and thermal stimuli influencing processes like inflammation and pain perception.

TRPV2 modulation impacts conditions such as cardiac hypertrophy and neurodegenerative disorders. TRPV2 interacts with proteins like calmodulin and various ion channels affecting cellular calcium dynamics that can lead to pathological states. Studies indicate that TRPV2 may play a part in the pathogenesis of heart diseases providing a link between mechanical stimuli and the development of cardiac-related conditions. Additionally aberrant regulation of TRPV2 has been implicated in muscular dystrophy highlighting its role in muscular maintenance and degradation processes.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

See full target information TRPV2

style

left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The journal of headache and pain 26:47 PubMed40045241

2025

Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine.

Applications

Unspecified application

Species

Unspecified reactive species

Qingling Zhai,Qihui Chen,Ning Zhang,Hongyan Li,Qijun Yu,Yonghui Pan

Circulation 148:1819-1822 PubMed38011244

2023

Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility.

Applications

Unspecified application

Species

Unspecified reactive species

Ming He,Jianjie Dong,Junmao Wen,Yuqing Zhang,So Yun Han,Chen Wang,Brendan Gongol,Tong-You Wade Wei,Jian Kang,Hsi-Yuan Huang,Susan Cheng,John Y-J Shyy

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TRPV2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV2 antibody (AB272862)

Western blot - Anti-TRPV2 antibody (AB272862)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise