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AB6183

Anti-TRPV2 antibody

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(6 Publications)

Rabbit Polyclonal TRPV2 antibody. Suitable for Dot, WB, IHC-Fr and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Rat Trpv2 aa 700 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Sac2b, Vrl1, Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, Stretch-activated channel 2B, Vanilloid receptor-like protein 1, OTRPC2, VRL-1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

Dot, WB, IHC-Fr

applications

Immunogen

Synthetic Peptide within Rat Trpv2 aa 700 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9WUD2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "Dot" : {"fullname" : "Dot Blot", "shortname":"Dot"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 7.4
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Add glycerol to a final volume of 50% for extra stability and aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRPV2 also known as transient receptor potential cation channel subfamily V member 2 is a non-selective cation channel with a molecular mass of around 85 kDa. Known for being heat-activated TRPV2 is sensitive to temperatures above 52°C. The protein is expressed in various tissues including heart lung spleen and brain. In neuronal and non-neuronal cells TRPV2 plays a role in calcium influx responding to potential mechanical stretch stimuli and cannabinoids like cannabidiol.
Biological function summary

TRPV2 acts as a sensor within cells and is vital for regulating calcium homeostasis affecting cellular responses in many types of cells. TRPV2 is not part of any multi-subunit complex but is often found located on the cell membrane where it modulates membrane potential and intracellular signaling. This protein contributes to tracking endogenous lipids for cellular signaling pathways necessary for various biological processes like muscle contraction and immune response.

Pathways

TRPV2 engages in cellular signaling pathways that modulate physiological responses. In particular it is part of the mechanotransduction and thermal sensing pathways where it interacts with proteins such as TRPV1 TRPV3 and TRPV4. These pathways are important for interpreting and reacting to mechanical and thermal stimuli influencing processes like inflammation and pain perception.

TRPV2 modulation impacts conditions such as cardiac hypertrophy and neurodegenerative disorders. TRPV2 interacts with proteins like calmodulin and various ion channels affecting cellular calcium dynamics that can lead to pathological states. Studies indicate that TRPV2 may play a part in the pathogenesis of heart diseases providing a link between mechanical stimuli and the development of cardiac-related conditions. Additionally aberrant regulation of TRPV2 has been implicated in muscular dystrophy highlighting its role in muscular maintenance and degradation processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).
See full target information Trpv2
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed36292998

2022

The Protective Effect of CBD in a Model of In Vitro Ischemia May Be Mediated by Agonism on TRPV2 Channel and Microglia Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Daniele Lana,Elisa Landucci,Costanza Mazzantini,Giada Magni,Domenico Edoardo Pellegrini-Giampietro,Maria Grazia Giovannini

Oncotarget 9:33459-33470 PubMed30323891

2016

TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Mohamad Elbaz,Dinesh Ahirwar,Zhang Xiaoli,Xinyu Zhou,Maryam Lustberg,Mohd W Nasser,Konstantin Shilo,Ramesh K Ganju

Histochemistry and cell biology 132:423-33 PubMed19579031

2009

TRPV2 expression in rat oral mucosa.

Applications

IHC-FoFr

Species

Rat

Daiji Shimohira,Mizuho A Kido,Atsushi Danjo,Tomoka Takao,Bing Wang,Jing-Qi Zhang,Takayoshi Yamaza,Sadahiko Masuko,Masaaki Goto,Teruo Tanaka

Neuroscience letters 454:129-33 PubMed19429069

2009

Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells.

Applications

IHC-Fr

Species

Rat

Yoshio Yamamoto,Taku Hatakeyama,Kazuyuki Taniguchi

Journal of anatomy 211:775-83 PubMed17979952

2007

Distribution of TRPV1- and TRPV2-immunoreactive afferent nerve endings in rat trachea.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshio Yamamoto,Yoshikazu Sato,Kazuyuki Taniguchi

Brain research 1017:155-62 PubMed15261111

2004

Regulation of TRPV2 by axotomy in sympathetic, but not sensory neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew D Gaudet,Sarah J Williams,Lucy P-R Hwi,Matt S Ramer
View all publications
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