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AB231150

Anti-TRPV3 antibody

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(4 Publications)

Rabbit Polyclonal TRPV3 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRPV3 aa 650 to C-terminus.

View Alternative Names

Transient receptor potential cation channel subfamily V member 3, TrpV3, Vanilloid receptor-like 3, VRL-3, TRPV3

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (AB231150)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (AB231150)

Formalin-fixed, paraffin-embedded human kidney tissue stained for TRPV3 with ab231150 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (AB231150)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV3 antibody (AB231150)

Formalin-fixed, paraffin-embedded human breast cancer tissue stained for TRPV3 with ab231150 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-TRPV3 antibody (AB231150)
  • WB

Supplier Data

Western blot - Anti-TRPV3 antibody (AB231150)

All lanes:

Western blot - Anti-TRPV3 antibody (ab231150) at 2 µg/mL

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Rat cerebrum lysate

Predicted band size: 91 kDa

false

Western blot - Anti-TRPV3 antibody (AB231150)
  • WB

Supplier Data

Western blot - Anti-TRPV3 antibody (AB231150)

All lanes:

Western blot - Anti-TRPV3 antibody (ab231150) at 2 µg/mL

All lanes:

Recombinant human TRPV3 protein

Predicted band size: 91 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TRPV3 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NET8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TRPV3 protein also known as transient receptor potential cation channel subfamily V member 3 functions as a calcium-permeable channel primarily involved in thermoregulation. With a mass of approximately 91 kDa TRPV3 is activated by warm temperatures and certain chemical compounds including natural oils. It is widely expressed in keratinocytes of the skin as well as in sensory neurons and can be found in other tissues like the brain and hair follicles.
Biological function summary

TRPV3 contributes to temperature sensation and pain perception playing an important role in maintaining skin barrier homeostasis. TRPV3 functions as a homotetramer forming a channel that allows the entry of cations into cells. This channel activity regulates various processes including cell proliferation differentiation and survival especially in the skin cells. Mutations or dysregulation in TRPV3 can result in abnormal skin physiology highlighting its function in epidermal biology.

Pathways

TRPV3 interacts closely with the TRP channel family and integrates into the calcium signaling and MAPK signaling pathways. Within these pathways TRPV3 modulates intracellular calcium levels affecting processes like inflammation and pain signaling. It closely associates with other TRP channels such as TRPV1 which is involved in mediating pain and heat sensation providing a coordinated response to environmental changes.

TRPV3 is linked to conditions such as Olmsted syndrome and atopic dermatitis both characterized by skin abnormalities. In Olmsted syndrome mutations in TRPV3 disrupt normal calcium influx leading to symptoms like palmoplantar keratoderma. Additionally TRPV3 dysregulation might exacerbate atopic dermatitis possibly through interactions with the protein filaggrin which is important for skin barrier function. Understanding TRPV3's role in these contexts can offer insights into potential therapeutic targets for skin-related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling : TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
See full target information TRPV3
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 38:1295-1306 PubMed36714978

2023

Hsa_circ_0072765 knockdown inhibits proliferation, activation and migration in transforming growth factor-beta (TGF-β)-induced hepatic stellate cells (HSCs) by the miR-197-3p/TRPV3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Jin,Xueyan Guo,Rong Zhang,Chunying Yan

Journal of gastrointestinal oncology 13:2447-2457 PubMed36388700

2022

TRPV3 inhibits colorectal cancer cell proliferation and migration by regulating the MAPK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Yu,Jieping Huang,Hui Yu,Jingping Lin,Fang Fan,Ruixiang Xie,Yongshi Shen,Kangni Lin,Yong Ye,Jinsen Weng

Molecular medicine reports 23: PubMed33760220

2021

MST1 inhibits the progression of breast cancer by regulating the Hippo signaling pathway and may serve as a prognostic biomarker.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Jin,Lihua Zhu,Sheng Xiao,Zhuhong Cui,Jing Tang,Jiangyong Yu,Mingjun Xie

European journal of obstetrics & gynecology and reproductive biology: X 10:100124 PubMed33733088

2021

Activation of TRPV4 channels leads to a consistent tocolytic effect on human myometrial tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Daniela Villegas,Olivier Giard,Karine Brochu-Gaudreau,Éric Rousseau
View all publications
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