Anti-TRPV3 antibody [N15/4]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The TRPV3 protein also known as transient receptor potential cation channel subfamily V member 3 functions as a calcium-permeable channel primarily involved in thermoregulation. With a mass of approximately 91 kDa TRPV3 is activated by warm temperatures and certain chemical compounds including natural oils. It is widely expressed in keratinocytes of the skin as well as in sensory neurons and can be found in other tissues like the brain and hair follicles.

Biological function summary

TRPV3 contributes to temperature sensation and pain perception playing an important role in maintaining skin barrier homeostasis. TRPV3 functions as a homotetramer forming a channel that allows the entry of cations into cells. This channel activity regulates various processes including cell proliferation differentiation and survival especially in the skin cells. Mutations or dysregulation in TRPV3 can result in abnormal skin physiology highlighting its function in epidermal biology.

Pathways

TRPV3 interacts closely with the TRP channel family and integrates into the calcium signaling and MAPK signaling pathways. Within these pathways TRPV3 modulates intracellular calcium levels affecting processes like inflammation and pain signaling. It closely associates with other TRP channels such as TRPV1 which is involved in mediating pain and heat sensation providing a coordinated response to environmental changes.

Associated diseases and disorders

TRPV3 is linked to conditions such as Olmsted syndrome and atopic dermatitis both characterized by skin abnormalities. In Olmsted syndrome mutations in TRPV3 disrupt normal calcium influx leading to symptoms like palmoplantar keratoderma. Additionally TRPV3 dysregulation might exacerbate atopic dermatitis possibly through interactions with the protein filaggrin which is important for skin barrier function. Understanding TRPV3's role in these contexts can offer insights into potential therapeutic targets for skin-related disorders.