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AB166898

Anti-Trypsinogen antibody [EPR11665(B)]

5

(1 Review)

|

(3 Publications)

Rabbit Recombinant Monoclonal PRSS2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

TRY2, TRYP2, PRSS2, Trypsin-2, Anionic trypsinogen, Serine protease 2, Trypsin II

1 Images
Western blot - Anti-Trypsinogen antibody [EPR11665(B)] (AB166898)
  • WB

Unknown

Western blot - Anti-Trypsinogen antibody [EPR11665(B)] (AB166898)

All lanes:

Western blot - Anti-Trypsinogen antibody [EPR11665(B)] (ab166898) at 1/1000 dilution

All lanes:

Human pancreas lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP antibody at 1/2000 dilution

Predicted band size: 26 kDa

false

  • Carrier free

    Anti-Trypsinogen antibody [EPR11665(B)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11665(B)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Trypsinogen also known as inactive trypsin is a precursor molecule that becomes active trypsin in the digestive system. It has a molecular mass of approximately 24 kDa. Secretory cells of the pancreas express trypsinogen and it is released into the small intestine as an inactive enzyme. In the small intestine enteropeptidase cleaves trypsinogen to form active trypsin which is important in digestion.
Biological function summary

Trypsinogen plays a role in converting proteins to peptides in the small intestine. It is part of the digestive system and contributes to the breakdown and absorption of proteins. Once activated to trypsin it works in tandem with other digestive enzymes like chymotrypsin and elastase. This teamwork ensures efficient digestion and absorption of nutrients.

Pathways

Trypsinogen is an important component in the digestive enzyme cascade. It plays a critical role in the proteolytic pathway which includes proteins like chymotrypsinogen and procarboxypeptidase. Activation of trypsin by enteropeptidase also promotes the activation of other zymogens thereby ensuring complete conversion of these inactive precursors to active enzymes vital for maintaining protein digestion.

An accumulation of trypsinogen can link to pancreatitis. This condition occurs when trypsinogen is prematurely activated within the pancreas leading to inflammation and tissue damage. Hereditary pancreatitis involves mutations in trypsinogen that result in increased autoactivation. Additionally cystic fibrosis can interfere with trypsinogen secretion and activation affecting pancreatic and digestive functions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

In the ileum, may be involved in defensin processing, including DEFA5.
See full target information PRSS2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 12: PubMed36008957

2022

The Rabep1-Mediated Endocytosis and Activation of Trypsinogen to Promote Pancreatic Stellate Cell Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Wenchao Yao,Dankun Luo,Zhenyi Lv,Yang Yang,Liyi Wang,Biao Ma,Dongbo Xue,Chenjun Hao,Yingmei Zhang

BMC gastroenterology 22:72 PubMed35183119

2022

Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Wenwen Xia,Zhaomin Lu,Wei Chen,Jianjun Zhou,Yan Zhao

Experimental & molecular medicine 50:1-13 PubMed30305605

2018

Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Gerrit Wolters-Eisfeld,Baris Mercanoglu,Bianca T Hofmann,Thomas Wolpers,Claudia Schnabel,Sönke Harder,Pascal Steffen,Kai Bachmann,Babett Steglich,Jörg Schrader,Nicola Gagliani,Hartmut Schlüter,Cenap Güngör,Jakob R Izbicki,Christoph Wagener,Maximilian Bockhorn
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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