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AB235313

Anti-TSGA10 antibody

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Rabbit Polyclonal TSGA10 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TSGA10 aa 1-200.

View Alternative Names

CEP4L, TSGA10, Testis-specific gene 10 protein, Testis development protein NYD-SP7

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSGA10 antibody (AB235313)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSGA10 antibody (AB235313)

Paraffin-embedded human testis tissue stained for TSGA10 using ab235313 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSGA10 antibody (AB235313)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSGA10 antibody (AB235313)

Paraffin-embedded human prostate cancer tissue stained for TSGA10 using ab235313 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-TSGA10 antibody (AB235313)
  • WB

Supplier Data

Western blot - Anti-TSGA10 antibody (AB235313)

All lanes:

Western blot - Anti-TSGA10 antibody (ab235313) at 1/500 dilution

All lanes:

U-251 MG (Human brain glioma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 81 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TSGA10 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9BZW7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Testis Specific 10 known as TSGA10 has an important role in cellular functions related to spermatogenesis. TSGA10 has a molecular weight of approximately 82 kDa. Expression of TSGA10 occurs mainly in the testis but it is also detected at lower levels in other tissues like the brain and some cancerous tissues. These expression patterns suggest a distinctive role for TSGA10 in reproductive biology.
Biological function summary

TSGA10 plays a role in the formation of spermatozoa. It localizes to the centrosome and is important for proper development of the flagella which is essential for sperm motility. TSGA10 forms part of a larger protein complex involved in the maturation and stabilization of microtubules necessary for cell division and motility. Microtubule-associated protein RP/EB family member 1 (MAPRE1) often interacts with TSGA10 to support these cellular functions.

Pathways

TSGA10 plays a part in pathways critical to reproductive cell development. It participates in the flagellar assembly pathway essential for the generation of functional sperm. TSGA10 interacts with proteins like kinesins which are motor proteins that move along microtubules. These interactions help support the mechanical action required for cellular movement and division within the reproductive system.

TSGA10 has been implicated in certain reproductive and cancer-related conditions. Abnormal expression of TSGA10 links to infertility issues often due to impaired sperm motility or structure. Furthermore TSGA10 shows higher expression levels in some cancers such as liver cancer suggesting a possible role in tumor progression. In these cancer contexts TSGA10 interacts with proteins like heat shock proteins (HSPs) which may aid in cancer cell survival and proliferation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in spermatogenesis (PubMed : 28905369). When overexpressed, prevents nuclear localization of HIF1A (By similarity).
See full target information TSGA10
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Product promise

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