JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB6069

Anti-TSH beta antibody [11E4]

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Monoclonal TSH beta antibody. Suitable for sELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human Thyrotropin subunit beta.

View Alternative Names

Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, Thyrotropin beta chain, TSH-B, TSH-beta, TSHB

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

11E4

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

sELISA

applications

Immunogen

Native Full Length Protein corresponding to Human Thyrotropin subunit beta.

P01222

Specificity

This antibody specifically recognizes ß-subunit of human TSH.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
style
left-column

Product details

This antibody (capture) is ELISA paired with ab6070 (conjugate).
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purity is tested by electrophoresis.
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSH beta also known as thyrotropin beta is a subunit of the thyroid-stimulating hormone (TSH). This hormone is a glycoprotein with a significant role in regulating the endocrine system. With a molecular mass of approximately 15 kDa TSH beta is one of the two subunits that together form the functional TSH. It is produced and expressed by the anterior pituitary gland. The beta subunit confers the hormone its specificity by interacting with the TSH receptor on thyroid cells.
Biological function summary

Thyrotropin beta ensures the thyroid gland functions properly by stimulating it to release thyroxine (T4) and triiodothyronine (T3). These thyroid hormones are essential for regulating metabolism in the body. TSH beta as a part of the TSH complex must combine with the alpha subunit to exhibit full biological activity. The production and secretion of TSH are tightly controlled by the hypothalamus-pituitary-thyroid axis which adjusts TSH levels based on the body's hormone requirements.

Pathways

TSH beta has a prominent role in the hypothalamus-pituitary-thyroid axis which is fundamental in thyroid hormone regulation. This pathway involves TRH (thyrotropin-releasing hormone) from the hypothalamus which stimulates the anterior pituitary to secrete TSH. In turn TSH interacts with its receptor on the thyroid gland promoting thyroid hormone synthesis. The pathway includes feedback mechanisms where increasing levels of T3 and T4 inhibit both TRH and TSH release maintaining homeostasis.

TSH beta is linked to conditions like hyperthyroidism and hypothyroidism which result from imbalances in thyroid hormone levels. In hyperthyroidism excess production of T3 and T4 occurs often due to TSH receptor overstimulation while in hypothyroidism inadequate production might arise from insufficient TSH levels leading to decreased thyroid hormone output. Disorders with TSH beta involvement may also relate to antibodies in conditions like Graves' disease where autoantibodies target the TSH receptor causing thyroid dysfunction.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Indispensable for the control of thyroid structure and metabolism.
See full target information Thyrotropin subunit beta
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 9:221 PubMed29615904

2018

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Qatato,Joanna Szumska,Vladislav Skripnik,Eddy Rijntjes,Josef Köhrle,Klaudia Brix
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB64378

Anti-TSH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSH antibody (AB64378)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB218108

Anti-TSH Receptor/TSH-R antibody [EPR19751]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSH Receptor/TSH-R antibody [EPR19751] (AB218108)

  • 1
  • 1
Primary Antibodies

AB92738

Anti-CGA/hCG alpha antibody [EP3373]

BOND RX™ Validated|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGA/hCG alpha antibody [EP3373] (AB92738)

  • 0
  • 0
Assay Kits

AB272194

Human CG beta ELISA Kit (CGB3)

Recombinant|SimpleStep

Sandwich ELISA - Human CG beta ELISA Kit (CGB3) (AB272194)

  • 0
  • 0
Primary Antibodies

AB130750

Anti-Luteinizing Hormone antibody [SP132]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Luteinizing Hormone antibody [SP132] (AB130750)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com