Rabbit Polyclonal TSH beta antibody. Suitable for WB and reacts with Dog, Recombinant full length protein - Dog samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Dog Thyrotropin subunit beta aa 1 to C-terminus.
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Publications
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- General and comparative endocrinology 294:1134952020Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAustin Weber et. al.PubMed 32360559
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Dog Thyrotropin subunit beta aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P54828
Reactivity data
Select an application| WB | |
|---|---|
| Human | Predicted |
| Cat | Predicted |
| Cow | Predicted |
| Dog | Tested |
| Horse | Predicted |
| Pig | Predicted |
| Recombinant full length protein - Dog | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Dog | Dilution info 0.50000-2.00000 µg/mL | Notes - |
Species Recombinant full length protein - Dog | Dilution info 0.50000-2.00000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Horse, Cow, Cat, Human, Pig | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Indispensable for the control of thyroid structure and metabolism.
Additional Targets
TSH beta
Alternative names
Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, Thyrotropin beta chain, TSH-B, TSH-beta, TSHB
Recommended products
Rabbit Polyclonal TSH beta antibody. Suitable for WB and reacts with Dog, Recombinant full length protein - Dog samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Dog Thyrotropin subunit beta aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Dog Thyrotropin subunit beta aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P54828
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TSH beta also known as thyrotropin beta is a subunit of the thyroid-stimulating hormone (TSH). This hormone is a glycoprotein with a significant role in regulating the endocrine system. With a molecular mass of approximately 15 kDa TSH beta is one of the two subunits that together form the functional TSH. It is produced and expressed by the anterior pituitary gland. The beta subunit confers the hormone its specificity by interacting with the TSH receptor on thyroid cells.
- Biological function summary
Thyrotropin beta ensures the thyroid gland functions properly by stimulating it to release thyroxine (T4) and triiodothyronine (T3). These thyroid hormones are essential for regulating metabolism in the body. TSH beta as a part of the TSH complex must combine with the alpha subunit to exhibit full biological activity. The production and secretion of TSH are tightly controlled by the hypothalamus-pituitary-thyroid axis which adjusts TSH levels based on the body's hormone requirements.
- Pathways
TSH beta has a prominent role in the hypothalamus-pituitary-thyroid axis which is fundamental in thyroid hormone regulation. This pathway involves TRH (thyrotropin-releasing hormone) from the hypothalamus which stimulates the anterior pituitary to secrete TSH. In turn TSH interacts with its receptor on the thyroid gland promoting thyroid hormone synthesis. The pathway includes feedback mechanisms where increasing levels of T3 and T4 inhibit both TRH and TSH release maintaining homeostasis.
- Associated diseases and disorders
TSH beta is linked to conditions like hyperthyroidism and hypothyroidism which result from imbalances in thyroid hormone levels. In hyperthyroidism excess production of T3 and T4 occurs often due to TSH receptor overstimulation while in hypothyroidism inadequate production might arise from insufficient TSH levels leading to decreased thyroid hormone output. Disorders with TSH beta involvement may also relate to antibodies in conditions like Graves' disease where autoantibodies target the TSH receptor causing thyroid dysfunction.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-TSH beta antibody (ab231218)
All lanes: Western blot - Anti-TSH beta antibody (ab231218) at 3 µg/mL
All lanes: Dog serum
SecondaryAll lanes: HRP-linked Guinea pig Anti-Rabbit at 1/2000 dilution
Predicted band size: 16 kDa
Western blot - Anti-TSH beta antibody (ab231218)
All lanes: Western blot - Anti-TSH beta antibody (ab231218) at 2 µg/mL
All lanes: Recombinant dog TSH beta protein
Predicted band size: 16 kDa
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