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AB254619

Anti-TSHZ1 antibody

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(1 Publication)

Rabbit Polyclonal TSHZ1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TSHZ1 aa 50-250.

View Alternative Names

SDCCAG33, TSH1, TSHZ1, Teashirt homolog 1, Antigen NY-CO-33, Serologically defined colon cancer antigen 33

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-TSHZ1 antibody (AB254619)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TSHZ1 antibody (AB254619)

PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling TSHZ1 using ab254619 at 4µg/ml (green) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSHZ1 antibody (AB254619)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSHZ1 antibody (AB254619)

Paraffin-embedded human pancreas tissue stained for TSHZ1 using ab254619 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-TSHZ1 antibody (AB254619)
  • WB

Supplier Data

Western blot - Anti-TSHZ1 antibody (AB254619)

Lane 1:

Western blot - Anti-TSHZ1 antibody (ab254619)

Lane 2:

Western blot - Anti-TSHZ1 antibody (ab254619) at 0.4 µg/mL

All lanes:

RT4 (human urinary bladder cancer cell line) cell lysate

Predicted band size: 118 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TSHZ1 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.

Q6ZSZ6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSHZ1 also known as Teashirt Zinc Finger Homeobox 1 is a transcription factor characterized by several zinc finger motifs. It has a molecular mass of approximately 123 kDa. This protein is expressed in a variety of tissues including the central nervous system skeletal muscle and lung. As a transcription factor TSHZ1 plays an important role in regulating gene expression by binding to specific DNA sequences.
Biological function summary

TSHZ1 participates in developmental processes particularly in the formation of the respiratory system and spinal cord. It acts as part of a complex with other transcription factors and co-factors to modulate gene expression. The protein regulates key developmental genes influencing cell differentiation and organogenesis.

Pathways

Research identifies TSHZ1 as an important component of the Notch signaling pathway where it interacts with proteins like CBF1 a major mediator of Notch signaling. TSHZ1 also contributes to the Wnt signaling pathway involved in cell fate determination embryonic development and tumorigenesis. The interplay of TSHZ1 with these pathways suggests its significant role in cellular development and differentiation.

Research links TSHZ1 to congenital central hypoventilation syndrome (CCHS). Abnormal TSHZ1 expression affects neuronal development contributing to CCHS pathogenesis. Additionally TSHZ1 ties to certain forms of deafness due to its role in the development of the inner ear. Its interactions with proteins such as PHOX2B another factor implicated in CCHS highlight its relevance in disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
See full target information TSHZ1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed37550000

2023

Macrophage promotes pathological neovascularization in age-related macular degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Yafang Wang,Yang Liu,Yan Wang,Yidong Wu,Zhixuan Chen,Feng Wang,Xiaoling Wan,Fenghua Wang,Xiaodong Sun
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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