Rabbit Polyclonal TSHZ1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TSHZ1 aa 50-250.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human TSHZ1 aa 50-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZSZ6
Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
Alternative names
SDCCAG33, TSH1, TSHZ1, Teashirt homolog 1, Antigen NY-CO-33, Serologically defined colon cancer antigen 33
Recommended products
Rabbit Polyclonal TSHZ1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TSHZ1 aa 50-250.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human TSHZ1 aa 50-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZSZ6
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TSHZ1 also known as Teashirt Zinc Finger Homeobox 1 is a transcription factor characterized by several zinc finger motifs. It has a molecular mass of approximately 123 kDa. This protein is expressed in a variety of tissues including the central nervous system skeletal muscle and lung. As a transcription factor TSHZ1 plays an important role in regulating gene expression by binding to specific DNA sequences.
- Biological function summary
TSHZ1 participates in developmental processes particularly in the formation of the respiratory system and spinal cord. It acts as part of a complex with other transcription factors and co-factors to modulate gene expression. The protein regulates key developmental genes influencing cell differentiation and organogenesis.
- Pathways
Research identifies TSHZ1 as an important component of the Notch signaling pathway where it interacts with proteins like CBF1 a major mediator of Notch signaling. TSHZ1 also contributes to the Wnt signaling pathway involved in cell fate determination embryonic development and tumorigenesis. The interplay of TSHZ1 with these pathways suggests its significant role in cellular development and differentiation.
- Associated diseases and disorders
Research links TSHZ1 to congenital central hypoventilation syndrome (CCHS). Abnormal TSHZ1 expression affects neuronal development contributing to CCHS pathogenesis. Additionally TSHZ1 ties to certain forms of deafness due to its role in the development of the inner ear. Its interactions with proteins such as PHOX2B another factor implicated in CCHS highlight its relevance in disease mechanisms.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSHZ1 antibody (ab254619)
Paraffin-embedded human pancreas tissue stained for TSHZ1 using ab254619 at 1/50 dilution in immunohistochemical analysis.
Western blot - Anti-TSHZ1 antibody (ab254619)
Lane 1: Western blot - Anti-TSHZ1 antibody (ab254619)
Lane 2: Western blot - Anti-TSHZ1 antibody (ab254619) at 0.4 µg/mL
All lanes: RT4 (human urinary bladder cancer cell line) cell lysate
Predicted band size: 118 kDa
Immunocytochemistry/ Immunofluorescence - Anti-TSHZ1 antibody (ab254619)
PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling TSHZ1 using ab254619 at 4µg/ml (green) in ICC/IF.
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