Rabbit Polyclonal Tspan-13 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human TSPAN13.
pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: 99% PBS
IHC-P | |
---|---|
Human | Tested |
Mouse | Predicted |
Rat | Predicted |
Bat | Predicted |
Common marmoset | Predicted |
Cow | Predicted |
Dog | Predicted |
Elephant | Predicted |
Gorilla | Predicted |
Hamster | Predicted |
Horse | Predicted |
Monkey | Predicted |
Opossum | Predicted |
Platypus | Predicted |
Rabbit | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Rabbit, Horse, Hamster, Dog, Monkey, Gorilla, Opossum, Common marmoset, Bat, Platypus, Elephant, Cow | Dilution info - | Notes - |
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NET6, TM4SF13, UNQ260/PRO296, TSPAN13, Tetraspanin-13, Tspan-13, Tetraspan NET-6, Transmembrane 4 superfamily member 13
Rabbit Polyclonal Tspan-13 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human TSPAN13.
pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: 99% PBS
BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Tspan-13 also known as Tetraspanin 13 is a member of the tetraspanin family which are small proteins characterized by four transmembrane domains. Tspan-13 has a molecular weight of around 26 kDa and consists of a short cytoplasmic N-terminal domain four hydrophobic transmembrane domains one small and one large extracellular loop and a cytoplasmic C-terminal tail. The large extracellular loop contains conserved CCG motifs typical of tetraspanins. Tspan-13 is expressed in various tissues including the immune system such as lymphoid organs and neural tissues suggesting diverse roles throughout the body.
Tspan-13 influences cell development and immune response through its role in cellular signal transduction. This protein is not just a structural component; it participates in forming tetraspanin-enriched microdomains which facilitates interactions between other proteins such as integrins and growth factor receptors. Within these microdomains Tspan-13 can modulate cell adhesion migration and proliferation which are essential processes for immune function and tissue repair.
Studies show Tspan-13 as being involved in the integrin signaling pathway and the epidermal growth factor receptor (EGFR) signaling pathway. These pathways are significant for cellular communication and adaptation to environmental changes. In the integrin signaling pathway Tspan-13 interacts with integrin β1 modulating cell adhesion and mobility. Within the EGFR pathway Tspan-13 impacts cell proliferation and survival. Both pathways highlight Tspan-13’s role in orchestrating key cellular functions that ensure tissue homeostasis.
Research links Tspan-13 to cancer and immune-related diseases. In cancer Tspan-13 expression influences tumor progression through its involvement in cell adhesion and migration affecting metastasis. Additionally irregularities in Tspan-13 interactions with integrins may contribute to autoimmune conditions where immune cells improperly attack healthy tissue. Understanding these associations can aid in developing therapeutic strategies targeting Tspan-13 to control disease progression.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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Terms & Conditions.
ab133366, at 10 µg/ml, staining Tspan-13 in Formalin-fixed, Paraffin-embedded Human stomach tissue by Immunohistochemistry.
ab133366, at 10 µg/ml, staining Tspan-13 in Formalin-fixed, Paraffin-embedded Human prostate tissue by Immunohistochemistry.
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