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Rabbit Polyclonal Tspan-13 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human TSPAN13.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (AB133366), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (AB133366), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: 99% PBS

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Synthetic Peptide within Human TSPAN13. The exact immunogen used to generate this antibody is proprietary information. Database link O95857

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Rat
Predicted
Bat
Predicted
Common marmoset
Predicted
Cow
Predicted
Dog
Predicted
Elephant
Predicted
Gorilla
Predicted
Hamster
Predicted
Horse
Predicted
Monkey
Predicted
Opossum
Predicted
Platypus
Predicted
Rabbit
Predicted

Tested
Tested

Species
Human
Dilution info
10 µg/mL
Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Predicted
Predicted

Species
Mouse, Rat, Rabbit, Horse, Hamster, Dog, Monkey, Gorilla, Opossum, Common marmoset, Bat, Platypus, Elephant, Cow
Dilution info
-
Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Alternative names

Recommended products

Rabbit Polyclonal Tspan-13 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human TSPAN13.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Synthetic Peptide within Human TSPAN13. The exact immunogen used to generate this antibody is proprietary information. Database link O95857
Purification technique
Affinity purification Immunogen
Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Tspan-13 also known as Tetraspanin 13 is a member of the tetraspanin family which are small proteins characterized by four transmembrane domains. Tspan-13 has a molecular weight of around 26 kDa and consists of a short cytoplasmic N-terminal domain four hydrophobic transmembrane domains one small and one large extracellular loop and a cytoplasmic C-terminal tail. The large extracellular loop contains conserved CCG motifs typical of tetraspanins. Tspan-13 is expressed in various tissues including the immune system such as lymphoid organs and neural tissues suggesting diverse roles throughout the body.

Biological function summary

Tspan-13 influences cell development and immune response through its role in cellular signal transduction. This protein is not just a structural component; it participates in forming tetraspanin-enriched microdomains which facilitates interactions between other proteins such as integrins and growth factor receptors. Within these microdomains Tspan-13 can modulate cell adhesion migration and proliferation which are essential processes for immune function and tissue repair.

Pathways

Studies show Tspan-13 as being involved in the integrin signaling pathway and the epidermal growth factor receptor (EGFR) signaling pathway. These pathways are significant for cellular communication and adaptation to environmental changes. In the integrin signaling pathway Tspan-13 interacts with integrin β1 modulating cell adhesion and mobility. Within the EGFR pathway Tspan-13 impacts cell proliferation and survival. Both pathways highlight Tspan-13’s role in orchestrating key cellular functions that ensure tissue homeostasis.

Associated diseases and disorders

Research links Tspan-13 to cancer and immune-related diseases. In cancer Tspan-13 expression influences tumor progression through its involvement in cell adhesion and migration affecting metastasis. Additionally irregularities in Tspan-13 interactions with integrins may contribute to autoimmune conditions where immune cells improperly attack healthy tissue. Understanding these associations can aid in developing therapeutic strategies targeting Tspan-13 to control disease progression.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (ab133366), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (ab133366)

    ab133366, at 10 µg/ml, staining Tspan-13 in Formalin-fixed, Paraffin-embedded Human stomach tissue by Immunohistochemistry.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (ab133366), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (ab133366)

    ab133366, at 10 µg/ml, staining Tspan-13 in Formalin-fixed, Paraffin-embedded Human prostate tissue by Immunohistochemistry.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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