Anti-Tspan-9 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Tspan-9 also known as Tetraspanin-9 is a protein involved in various cellular processes like cell adhesion proliferation and migration. This protein belongs to the tetraspanin superfamily characterized by four transmembrane domains. Tspan-9 has a molecular mass of approximately 26 kDa. Research shows that Tspan-9 is expressed in several tissues including the immune system's components such as leukocytes indicating its diverse role in immune functionality and cellular communication.

Biological function summary

Tspan-9 influences cell signaling pathways through interactions with other tetraspanins and membrane proteins. Tspan-9 associations with integrins facilitate the organization of signaling complexes that mediate cellular responses. It often forms complexes with proteins involved in maintaining the cell membrane's structural integrity. These interactions show its role in controlling cellular behavior relevant to growth and communication between cells.

Pathways

Tspan-9 plays a role in the regulation of integrin-mediated signaling and the PI3K/AKT signaling pathway. Tspan-9 interacts with proteins such as CD9 and integrins affecting pathways instrumental in cell survival and proliferation. These interactions contribute to cellular adhesion dynamics demonstrating Tspan-9's role in facilitating important cellular processes.

Associated diseases and disorders

Alterations in Tspan-9 expression have a connection to certain cancer types. Specifically Tspan-9 modulates processes in tumor development and metastasis. Its interactions with proteins like CD9 have implications in cancer pathology affecting tumor growth and invasive potential. Additionally abnormalities in Tspan-9 function or regulation may link to immunological disorders reflecting its role in immune system modulation.