Rabbit Polyclonal TSPAN11 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Tetraspanin-11 aa 100-200.
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Publications
Filter by
- Oncology letters 14:6815-68222017Expression and function of tetraspanin 1 in esophageal carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTingting Gu et. al.PubMed 29422958
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Tetraspanin-11 aa 100-200. The exact immunogen used to generate this antibody is proprietary information. Database link A1L157
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
| Cow | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow | Dilution info - | Notes - |
Target data
Alternative names
Tetraspanin-11, Tspan-11, TSPAN11
Recommended products
Rabbit Polyclonal TSPAN11 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Tetraspanin-11 aa 100-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Tetraspanin-11 aa 100-200. The exact immunogen used to generate this antibody is proprietary information. Database link A1L157
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TSPAN11 also known as tetraspanin-11 is a member of the tetraspanin family a group of proteins characterized by four transmembrane domains. TSPAN11 has a molecular mass of approximately 24 kDa. It is expressed in various tissue types including lung kidney and immune cells. TSPAN11 proteins usually have essential roles in cellular processes through interactions with other transmembrane proteins and components of the cell membrane.
- Biological function summary
TSPAN11 participates actively in cell adhesion migration and proliferation. It is part of the tetraspanin web a complex arrangement of proteins on the cell surface. Tetraspanins like TSPAN11 facilitate the organization of molecular complexes known as tetraspanin-enriched microdomains (TEMs). These microdomains help regulate intracellular signaling pathways that are important for cellular events.
- Pathways
TSPAN11 influences cellular processes by engaging in the PI3K/AKT signaling pathway. It interacts with proteins such as integrins to mediate cell adhesion and migration. TSPAN11 also associates with proteins within the EGFR signaling pathway aiding in the modulation of cellular proliferation and survival. These interactions highlight TSPAN11's role in maintaining cellular function and response to external stimuli.
- Associated diseases and disorders
TSPAN11 links to certain cancers and immune-related diseases. Aberrant expression or dysfunction of TSPAN11 affects cell migration and adhesion contributing to cancer metastasis. It has connections with other proteins like integrin involved in these processes. Additionally TSPAN11 may play a role in autoimmune diseases by affecting immune cell functions interacting with proteins that regulate immune responses and inflammation.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry/ Immunofluorescence - Anti-TSPAN11 antibody (ab221740)
PFA-fixed, Triton X-100 permeabilized SH-SY5Y (human neuroblastoma cell line from bone marrow) cells stained for TSPAN11 (green) using ab221740 at 4 μg/ml in ICC/IF.
Western blot - Anti-TSPAN11 antibody (ab221740)
All lanes: Western blot - Anti-TSPAN11 antibody (ab221740) at 1/250 dilution
Lane 1: RT4 (human urinary bladder cancer cell line) cell lysate
Lane 2: U-251 MG (human brain glioma cell line) cell lysate
Predicted band size: 28 kDa
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