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AB221740

Anti-TSPAN11 antibody

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(1 Publication)

Rabbit Polyclonal TSPAN11 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Tetraspanin-11 aa 100-200.

View Alternative Names

Tetraspanin-11, Tspan-11, TSPAN11

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-TSPAN11 antibody (AB221740)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TSPAN11 antibody (AB221740)

PFA-fixed, Triton X-100 permeabilized SH-SY5Y (human neuroblastoma cell line from bone marrow) cells stained for TSPAN11 (green) using ab221740 at 4 μg/ml in ICC/IF.

Western blot - Anti-TSPAN11 antibody (AB221740)
  • WB

Supplier Data

Western blot - Anti-TSPAN11 antibody (AB221740)

All lanes:

Western blot - Anti-TSPAN11 antibody (ab221740) at 1/250 dilution

Lane 1:

RT4 (human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG (human brain glioma cell line) cell lysate

Predicted band size: 28 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human Tetraspanin-11 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

A1L157

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSPAN11 also known as tetraspanin-11 is a member of the tetraspanin family a group of proteins characterized by four transmembrane domains. TSPAN11 has a molecular mass of approximately 24 kDa. It is expressed in various tissue types including lung kidney and immune cells. TSPAN11 proteins usually have essential roles in cellular processes through interactions with other transmembrane proteins and components of the cell membrane.
Biological function summary

TSPAN11 participates actively in cell adhesion migration and proliferation. It is part of the tetraspanin web a complex arrangement of proteins on the cell surface. Tetraspanins like TSPAN11 facilitate the organization of molecular complexes known as tetraspanin-enriched microdomains (TEMs). These microdomains help regulate intracellular signaling pathways that are important for cellular events.

Pathways

TSPAN11 influences cellular processes by engaging in the PI3K/AKT signaling pathway. It interacts with proteins such as integrins to mediate cell adhesion and migration. TSPAN11 also associates with proteins within the EGFR signaling pathway aiding in the modulation of cellular proliferation and survival. These interactions highlight TSPAN11's role in maintaining cellular function and response to external stimuli.

TSPAN11 links to certain cancers and immune-related diseases. Aberrant expression or dysfunction of TSPAN11 affects cell migration and adhesion contributing to cancer metastasis. It has connections with other proteins like integrin involved in these processes. Additionally TSPAN11 may play a role in autoimmune diseases by affecting immune cell functions interacting with proteins that regulate immune responses and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Tetraspanin-11
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 14:6815-6822 PubMed29422958

2017

Expression and function of tetraspanin 1 in esophageal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Gu,Weiwei Chen,Li Chen,Guilan Wang,Tiejun Li,Yuanyuan Zhu,Xiaojiao Gao
View all publications
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Product promise

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