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AB180502

Anti-TSPAN31 + Tspan-13 antibody [EPR11225(2)]

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(4 Publications)

Rabbit Recombinant Monoclonal TSPAN31 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.

View Alternative Names

SAS, TSPAN31, Tetraspanin-31, Tspan-31, Sarcoma-amplified sequence, NET6, TM4SF13, UNQ260/PRO296, TSPAN13, Tetraspanin-13, Tspan-13, Tetraspan NET-6, Transmembrane 4 superfamily member 13

1 Images
Western blot - Anti-TSPAN31 + Tspan-13 antibody [EPR11225(2)] (AB180502)
  • WB

Supplier Data

Western blot - Anti-TSPAN31 + Tspan-13 antibody [EPR11225(2)] (AB180502)

All lanes:

Western blot - Anti-TSPAN31 + Tspan-13 antibody [EPR11225(2)] (ab180502) at 1/5000 dilution

Lane 1:

Fetal heart lysate at 20 µg

Lane 2:

SW1353 cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase Conjugate at 1/1000 dilution

Predicted band size: 23 kDa

Observed band size: 23 kDa

false

  • Carrier free

    Anti-TSPAN31+Tspan-13 antibody [EPR11225(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11225(2)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSPAN31 also known as Tspan-13 is a protein that is part of the tetraspanin family. This group of membrane proteins plays a role in organizing the cellular membrane structure. TSPAN31 consists of four transmembrane domains and has a molecular mass of about 28 kDa. It is expressed broadly across different tissues but shows higher levels in certain cell types such as hematopoietic cells and various subsets of epithelial cells. Its unique structure allows it to interact with various other proteins and participate in microdomain formations on the cell surface.
Biological function summary

The protein facilitates interactions between cell surface receptors and intracellular signaling molecules. TSPAN31 is part of a multi-protein complex often engaging with integrins and other tetraspanins which influences cell signaling migration and adhesion. It contributes to organizing protein complexes in membrane microdomains which is essential for efficient signal transduction. This protein impacts processes like immune responses and epithelial cell function by modulating these cellular activities.

Pathways

TSPAN31 interacts with several signaling cascades such as MAPK/ERK and PI3K/AKT pathways. These pathways play a critical role in cell growth survival and differentiation. Its association with CD81 and integrins highlights its influence on these signal transduction pathways affecting cellular communication and response. These interactions emphasize TSPAN31's role in regulating signal flow within cellular environments impacting various homeostatic and stress-related processes.

TSPAN31 shows relevance to cancer and immune-related conditions. Overexpression or misregulation has been documented in certain cancers including leukemia and colorectal cancer suggesting its role in tumor progression and metastasis. In autoimmune disorders such as systemic lupus erythematosus TSPAN31's interaction with proteins like CD81 and others in the tetraspanin web affects immune cell signaling and activity linking it to disease onset and progression. Understanding these connections aids in the development of targeted therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TSPAN31

Additional targets

TSPAN13
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer science 113:1984-1998 PubMed35307915

2022

Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yusuke Takashima,Shuhei Komatsu,Takuma Ohashi,Jun Kiuchi,Hajime Kamiya,Hiroki Shimizu,Tomohiro Arita,Hirotaka Konishi,Atsushi Shiozaki,Takeshi Kubota,Kazuma Okamoto,Hitoshi Fujiwara,Hitoshi Tsuda,Eigo Otsuji

Cell biochemistry and function 38:660-668 PubMed32207169

2020

TSPAN31 suppresses cell proliferation in human cervical cancer through down-regulation of its antisense pairing with CDK4.

Applications

Unspecified application

Species

Unspecified reactive species

Yingjie Xia,Yuanfei Deng,Yuting Zhou,Dan Li,Xuemeng Sun,Lei Gu,Zipeng Chen,Qing Zhao

FEBS letters 591:2905-2918 PubMed28670683

2017

TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jianglin Wang,Yuting Zhou,Dan Li,Xuemeng Sun,Yuanfei Deng,Qing Zhao

Nature genetics 49:180-185 PubMed28067913

2017

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Simon Papillon-Cavanagh,Chao Lu,Tenzin Gayden,Leonie G Mikael,Denise Bechet,Christina Karamboulas,Laurie Ailles,Jason Karamchandani,Dylan M Marchione,Benjamin A Garcia,Ilan Weinreb,David Goldstein,Peter W Lewis,Octavia Maria Dancu,Sandeep Dhaliwal,William Stecho,Christopher J Howlett,Joe S Mymryk,John W Barrett,Anthony C Nichols,C David Allis,Jacek Majewski,Nada Jabado
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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