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AB236883

Anti-TSPAN6 antibody

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(1 Publication)

Rabbit Polyclonal TSPAN6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TSPAN6 aa 100 to C-terminus.

View Alternative Names

TM4SF6, UNQ767/PRO1560, TSPAN6, Tetraspanin-6, Tspan-6, A15 homolog, Putative NF-kappa-B-activating protein 321, T245 protein, Tetraspanin TM4-D, Transmembrane 4 superfamily member 6

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPAN6 antibody (AB236883)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPAN6 antibody (AB236883)

Paraffin-embedded human skin tissue stained for TSPAN6 with ab236883 at a 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-TSPAN6 antibody (AB236883)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TSPAN6 antibody (AB236883)

HepG2 (Human liver hepatocellular carcinoma cell line) cells stained for TSPAN6 using ab236883 at a dilution of 1/100 in ICC/IF. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TSPAN6 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43657

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSPAN6 also known as Tetraspanin-6 is a member of the tetraspanin protein family. This protein has a molecular mass of approximately 27 kDa. TSPAN6 is an integral membrane protein and typically resides in the plasma membrane. The protein is broadly expressed across a range of tissues including brain immune cells and various epithelial tissues. Tetraspanins generally play a role in organizing the structure of the cell surface membrane and TSPAN6 is believed to contribute to this structural framework as well.
Biological function summary

TSPAN6 participates in various cell processes by influencing the molecular interactions at the cell surface. As a member of the tetraspanin family it associates with other transmembrane proteins to form complexes. These complexes can regulate cell signaling adhesion and migration. As a result TSPAN6 plays a part in modulating immune response and cellular development processes. Its involvement in the packaging of molecules like other tetraspanins is important for processes such as cell communication and motility.

Pathways

TSPAN6 takes part in several signaling pathways including the Wnt signaling pathway. It interacts with other proteins like the beta-catenin to influence cell fate decisions and proliferation. TSPAN6 may also have a role within the regulation of the immune system pathways potentially through interaction with proteins such as integrins. This involvement can affect processes like immune surveillance and response to pathogens.

Aberrant expression of TSPAN6 has connections with neurological conditions and cancers. In neurodevelopmental disorders such as autism spectrum disorders changes in TSPAN6 expression may interfere with neural connectivity and communication. This protein has been implicated in cancer progression especially in colon cancer where it might modulate cell proliferation and migration. In these conditions TSPAN6 could be intertwined with proteins like EGFR affecting cellular growth and survival.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TSPAN6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Translational oncology 22:101454 PubMed35617811

2022

Suppression of FAM83D Inhibits Glioma Proliferation, Invasion and Migration by Regulating the AKT/mTOR Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xia Li,Cui Sun,Jing Chen,Ji-Fen Ma,Yi-Heng Pan
View all publications
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Product promise

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