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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal TSPY1/TSPY antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human TSPY1.
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Expected | Tested |
Mouse | Tested | Expected |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 0.50000-1.00000 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
May be involved in sperm differentiation and proliferation.
Testis-specific Y-encoded protein 1, Cancer/testis antigen 78, CT78, TSPY, TSPY1
Rabbit Polyclonal TSPY1/TSPY antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human TSPY1.
Testis-specific Y-encoded protein 1, Cancer/testis antigen 78, CT78, TSPY, TSPY1
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
At least three isoforms of TSPY1 are known to exist; this antibody will detect only TSPY1L (Isoform 2).
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
TSPY1 influences cellular division and differentiation within the testes. As part of the DNA-binding protein family it associates with other proteins to impact germ cell progression. TSPY1 plays a role in the maintenance and proliferation of spermatogonial cells which are precursors to sperm cells. Its involvement here links it closely with cell cycle regulation and meiotic processes.
TSPY1 also known as Testis-Specific Protein Y-Encoded is a Y-linked gene with a protein product weighing approximately 38 kDa. This protein is mainly expressed in male germ cells found in the testes. TSPY1 functions as a nucleosome assembly factor which implicates its role in chromatin remodeling and regulation of transcription. It shows specific expression in the testis indicating its role in spermatogenesis and fertility processes.
TSPY1 associates with regulatory processes important for the maintenance of spermatogonial stem cells. It participates in pathways including the Wnt signaling pathway which is essential for cell growth and differentiation. TSPY1 interacts with proteins such as Cyclin B influencing the G2/M transition during cell division. This interaction highlights its importance in ensuring proper cell cycle progression and indicates its pivotal role in reproductive biology.
TSPY1 has associations with testicular germ cell tumors and infertility. Abnormal expression of TSPY1 is found in a significant number of testicular cancer cases highlighting its oncogenic potential. It connects with oncogenes such as Cyclin D2 contributing to tumor cell proliferation. Furthermore deletions or duplications of TSPY1 might relate to spermatogenic failure causing male infertility. These associations highlight the importance of TSPY1 in both normal testicular function and its relevance in pathophysiological conditions.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Lane 1: Western blot - Anti-TSPY1/TSPY antibody - C-terminal (AB189962) at 0.5 µg/mL
Lane 2: Western blot - Anti-TSPY1/TSPY antibody - C-terminal (AB189962) at 1 µg/mL
All lanes: A20 cell lysate
Predicted band size: 35 kDa
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling TSPY1/TSPY with ab189962 at 5μg/ml.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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