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Rabbit Polyclonal TSPY1/TSPY antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human TSPY1.

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Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human TSPY1. The exact immunogen used to generate this antibody is proprietary information. Database link Q01534
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Expected
Tested
Mouse
Tested
Expected

Tested
Tested

Species

Mouse

Dilution info

0.50000-1.00000 µg/mL

Notes

-

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Tested
Tested

Species

Human

Dilution info

5 µg/mL

Notes

-

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Target data

Function

May be involved in sperm differentiation and proliferation.

Alternative names

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Rabbit Polyclonal TSPY1/TSPY antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human TSPY1.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human TSPY1. The exact immunogen used to generate this antibody is proprietary information. Database link Q01534
Purification technique

Affinity purification Immunogen

Specificity

At least three isoforms of TSPY1 are known to exist; this antibody will detect only TSPY1L (Isoform 2).

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

TSPY1 influences cellular division and differentiation within the testes. As part of the DNA-binding protein family it associates with other proteins to impact germ cell progression. TSPY1 plays a role in the maintenance and proliferation of spermatogonial cells which are precursors to sperm cells. Its involvement here links it closely with cell cycle regulation and meiotic processes.

Activity summary

TSPY1 also known as Testis-Specific Protein Y-Encoded is a Y-linked gene with a protein product weighing approximately 38 kDa. This protein is mainly expressed in male germ cells found in the testes. TSPY1 functions as a nucleosome assembly factor which implicates its role in chromatin remodeling and regulation of transcription. It shows specific expression in the testis indicating its role in spermatogenesis and fertility processes.

Pathways

TSPY1 associates with regulatory processes important for the maintenance of spermatogonial stem cells. It participates in pathways including the Wnt signaling pathway which is essential for cell growth and differentiation. TSPY1 interacts with proteins such as Cyclin B influencing the G2/M transition during cell division. This interaction highlights its importance in ensuring proper cell cycle progression and indicates its pivotal role in reproductive biology.

Associated diseases and disorders

TSPY1 has associations with testicular germ cell tumors and infertility. Abnormal expression of TSPY1 is found in a significant number of testicular cancer cases highlighting its oncogenic potential. It connects with oncogenes such as Cyclin D2 contributing to tumor cell proliferation. Furthermore deletions or duplications of TSPY1 might relate to spermatogenic failure causing male infertility. These associations highlight the importance of TSPY1 in both normal testicular function and its relevance in pathophysiological conditions.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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2 product images

  • Western blot - Anti-TSPY1/TSPY antibody - C-terminal (ab189962), expandable thumbnail

    Western blot - Anti-TSPY1/TSPY antibody - C-terminal (ab189962)

    Lane 1: Western blot - Anti-TSPY1/TSPY antibody - C-terminal (AB189962) at 0.5 µg/mL

    Lane 2: Western blot - Anti-TSPY1/TSPY antibody - C-terminal (AB189962) at 1 µg/mL

    All lanes: A20 cell lysate

    Predicted band size: 35 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPY1/TSPY antibody - C-terminal (ab189962), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPY1/TSPY antibody - C-terminal (ab189962)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling TSPY1/TSPY with ab189962 at 5μg/ml.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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