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AB189962

Anti-TSPY1/TSPY antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal TSPY1/TSPY antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TSPY1.

View Alternative Names

TSPY, TSPY1, Testis-specific Y-encoded protein 1, Cancer/testis antigen 78, CT78

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPY1/TSPY antibody - C-terminal (AB189962)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPY1/TSPY antibody - C-terminal (AB189962)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling TSPY1/TSPY with ab189962 at 5μg/ml.

Western blot - Anti-TSPY1/TSPY antibody - C-terminal (AB189962)
  • WB

Supplier Data

Western blot - Anti-TSPY1/TSPY antibody - C-terminal (AB189962)

Lane 1:

Western blot - Anti-TSPY1/TSPY antibody - C-terminal (ab189962) at 0.5 µg/mL

Lane 2:

Western blot - Anti-TSPY1/TSPY antibody - C-terminal (ab189962) at 1 µg/mL

All lanes:

A20 cell lysate

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human TSPY1. The exact immunogen used to generate this antibody is proprietary information.

Q01534

Specificity

At least three isoforms of TSPY1 are known to exist; this antibody will detect only TSPY1L (Isoform 2).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSPY1 also known as Testis-Specific Protein Y-Encoded is a Y-linked gene with a protein product weighing approximately 38 kDa. This protein is mainly expressed in male germ cells found in the testes. TSPY1 functions as a nucleosome assembly factor which implicates its role in chromatin remodeling and regulation of transcription. It shows specific expression in the testis indicating its role in spermatogenesis and fertility processes.
Biological function summary

TSPY1 influences cellular division and differentiation within the testes. As part of the DNA-binding protein family it associates with other proteins to impact germ cell progression. TSPY1 plays a role in the maintenance and proliferation of spermatogonial cells which are precursors to sperm cells. Its involvement here links it closely with cell cycle regulation and meiotic processes.

Pathways

TSPY1 associates with regulatory processes important for the maintenance of spermatogonial stem cells. It participates in pathways including the Wnt signaling pathway which is essential for cell growth and differentiation. TSPY1 interacts with proteins such as Cyclin B influencing the G2/M transition during cell division. This interaction highlights its importance in ensuring proper cell cycle progression and indicates its pivotal role in reproductive biology.

TSPY1 has associations with testicular germ cell tumors and infertility. Abnormal expression of TSPY1 is found in a significant number of testicular cancer cases highlighting its oncogenic potential. It connects with oncogenes such as Cyclin D2 contributing to tumor cell proliferation. Furthermore deletions or duplications of TSPY1 might relate to spermatogenic failure causing male infertility. These associations highlight the importance of TSPY1 in both normal testicular function and its relevance in pathophysiological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in sperm differentiation and proliferation.
See full target information TSPY1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 14:2268-2286 PubMed35255005

2022

A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1.

Applications

Unspecified application

Species

Unspecified reactive species

Xiwu Ouyang,Lemeng Feng,Lei Yao,Jingyu Zhang,Yao Xiao,Guodong Liu,Gewen Zhang,Zhiming Wang
View all publications
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Product promise

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