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AB220639

Anti-TSR1 antibody

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(1 Publication)

Rabbit Polyclonal TSR1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TSR1 aa 150-300.

View Alternative Names

KIAA1401, TSR1, Pre-rRNA-processing protein TSR1 homolog

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-TSR1 antibody (AB220639)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TSR1 antibody (AB220639)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-251 MG cells labeling ITCH/AIP4 with ab220639 at 4 μg/mL (green).

Western blot - Anti-TSR1 antibody (AB220639)
  • WB

Supplier Data

Western blot - Anti-TSR1 antibody (AB220639)

All lanes:

Western blot - Anti-TSR1 antibody (ab220639) at 1/100 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251 MG cell lysate

Predicted band size: 92 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human TSR1 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q2NL82

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TSR1 also known as 'ribosome biogenesis protein TSR1' is involved in pre-rRNA processing and stands significant in the maturation of the 40S ribosomal subunits. This protein has a mass of approximately 99 kDa and expresses itself in the nucleolus of cells contributing to the ribosome biogenesis pathway. TSR1 assists in converting the 90S precursor into pre-40S particles which later become functional 40S ribosomal subunits.
Biological function summary

The TSR1 protein plays a part in the formation of ribosomal subunits essential for protein synthesis within eukaryotic cells. This protein actively participates in a multiprotein complex called the small subunit (SSU) processome critical for pre-rRNA processing. TSR1 ensures proper assembly and stability of the small ribosomal subunit by interacting with other ribosome biogenesis factors ensuring efficient translation processes.

Pathways

TSR1 operates closely in the ribosome biogenesis pathway and the rRNA processing pathway. It forms associations with ribosomal proteins like RPS19 and proteins such as NOP14. These associations facilitate the maturation and processing of pre-rRNA linking TSR1's role directly to the production of essential components of the translational machinery vital for cellular function and growth.

Defects or mutations in TSR1 may associate with abnormally formed ribosomal subunits contributing to conditions such as Diamond-Blackfan anemia or other ribosomopathies. The connection between TSR1 and the ribosomal protein RPS19 suggests a potential impact on disorders marked by ineffective hematopoiesis. Understanding TSR1's interactions and pathways can provide insights into treating or managing ribosome-linked disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required during maturation of the 40S ribosomal subunit in the nucleolus.
See full target information TSR1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC biology 20:115 PubMed35581583

2022

Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Doo Soon Im,Alvin Joselin,Devon Svoboda,Tesuya Takano,Maxime W C Rousseaux,Steve Callaghan,Ruth S Slack,Shin-Ichi Hisanaga,Roger J Davis,David S Park,Dianbo Qu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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