Anti-TSR1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The TSR1 also known as 'ribosome biogenesis protein TSR1' is involved in pre-rRNA processing and stands significant in the maturation of the 40S ribosomal subunits. This protein has a mass of approximately 99 kDa and expresses itself in the nucleolus of cells contributing to the ribosome biogenesis pathway. TSR1 assists in converting the 90S precursor into pre-40S particles which later become functional 40S ribosomal subunits.

Biological function summary

The TSR1 protein plays a part in the formation of ribosomal subunits essential for protein synthesis within eukaryotic cells. This protein actively participates in a multiprotein complex called the small subunit (SSU) processome critical for pre-rRNA processing. TSR1 ensures proper assembly and stability of the small ribosomal subunit by interacting with other ribosome biogenesis factors ensuring efficient translation processes.

Pathways

TSR1 operates closely in the ribosome biogenesis pathway and the rRNA processing pathway. It forms associations with ribosomal proteins like RPS19 and proteins such as NOP14. These associations facilitate the maturation and processing of pre-rRNA linking TSR1's role directly to the production of essential components of the translational machinery vital for cellular function and growth.

Associated diseases and disorders

Defects or mutations in TSR1 may associate with abnormally formed ribosomal subunits contributing to conditions such as Diamond-Blackfan anemia or other ribosomopathies. The connection between TSR1 and the ribosomal protein RPS19 suggests a potential impact on disorders marked by ineffective hematopoiesis. Understanding TSR1's interactions and pathways can provide insights into treating or managing ribosome-linked disorders.