JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB127036

Anti-TSSK4 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal TSSK4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TSSK4 aa 1 to C-terminus.

View Alternative Names

C14orf20, STK22E, TSSK5, TSSK4, Testis-specific serine/threonine-protein kinase 4, TSK-4, TSSK-4, Testis-specific kinase 4, Serine/threonine-protein kinase 22E

1 Images
Western blot - Anti-TSSK4 antibody (AB127036)
  • WB

Unknown

Western blot - Anti-TSSK4 antibody (AB127036)

12% SDS PAGE

All lanes:

Western blot - Anti-TSSK4 antibody (ab127036) at 1/1000 dilution

All lanes:

NT2D1 whole cell lysate at 30 µg

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human TSSK4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6SA08

style
left-column

Complementary Products

Primary Antibodies

AB307678

Anti-VPS54 antibody [EPR28123-81]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-VPS54 antibody [EPR28123-81] (AB307678)

  • 0
  • 0
Primary Antibodies

AB96551

Anti-MAP4K5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MAP4K5 antibody (AB96551)

  • 4
  • 1
Primary Antibodies

AB111697

Anti-ZNF587 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF587 antibody (AB111697)

  • 0
  • 0
Primary Antibodies

AB127743

Anti-ZNF418 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF418 antibody (AB127743)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSSK4 also known as Testis-specific serine/threonine-protein kinase 4 functions as a serine/threonine kinase. It is involved in phosphorylating specific substrates playing a significant role in cell processes that require kinase activity. The protein has a mass of approximately 36 kDa. TSSK4 is expressed mainly in the testis pointing to a specialized function in testicular tissues. Researchers have also observed expression at lower levels in other tissues albeit much lesser than in the testis.
Biological function summary

TSSK4 plays a role in sperm development and maturation being actively involved in spermatogenesis. It does not act alone but instead is part of a larger protein complex. This involvement suggests its significant influence on reproductive processes. Its kinase activity can impact substrates necessary for the proper development of sperm cells ensuring the necessary modifications and regulatory signals are present.

Pathways

TSSK4 participates notably in signaling pathways related to male fertility like those that regulate spermatogenesis. It interacts with various proteins such as heat shock proteins which are regular participants in protein folding and stabilization. Such interactions present the involvement of TSSK4 in a tightly regulated series of events that maintain cell functionality and stability within reproductive tissues.

Deficiencies or malfunctions in TSSK4 have been connected to male infertility. Disruptions to its kinase functions can lead to impaired sperm development and low sperm motility leading to reproductive issues. Additionally some studies have shown associations between TSSK4 and conditions like Sertoli cell-only syndrome. In such contexts TSSK4's relationship to proteins involved in testicular development becomes a critical factor in understanding these reproductive disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed : 15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity).
See full target information TSSK4
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 134: PubMed39286971

2024

SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyan Ren,Weiqi Hong,Jingyun Yang,Jun Zou,Li Chen,Yanan Zhou,Hong Lei,Aqu Alu,Haiying Que,Yanqiu Gong,Zhenfei Bi,Cai He,Minyang Fu,Dandan Peng,Yun Yang,Wenhai Yu,Cong Tang,Qing Huang,Mengli Yang,Bai Li,Jingmei Li,Junbin Wang,Xuelei Ma,Hongbo Hu,Wei Cheng,Haohao Dong,Jian Lei,Lu Chen,Xikun Zhou,Jiong Li,Wei Wang,Guangwen Lu,Guobo Shen,Li Yang,Jinliang Yang,Zhenling Wang,Guowen Jia,Zhaoming Su,Bin Shao,Hanpei Miao,Johnson Yiu-Nam Lau,Yuquan Wei,Kang Zhang,Lunzhi Dai,Shuaiyao Lu,Xiawei Wei
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com