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AB155306

Anti-TSTA3 antibody

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(4 Publications)

Rabbit Polyclonal TSTA3 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GFUS aa 150 to C-terminus.

View Alternative Names

SDR4E1, TSTA3, GFUS, GDP-L-fucose synthase, Protein FX, Red cell NADP(H)-binding protein, Short-chain dehydrogenase/reductase family 4E member 1

1 Images
Western blot - Anti-TSTA3 antibody (AB155306)
  • WB

Unknown

Western blot - Anti-TSTA3 antibody (AB155306)

10% SDS PAGE

All lanes:

Western blot - Anti-TSTA3 antibody (ab155306) at 1/1000 dilution

Lane 1:

H1299 whole cell lysate at 30 µg

Lane 2:

HeLa whole cell lysate at 30 µg

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human GFUS aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q13630

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Trans-sialidase-related protein 3 (TSTA3) also known as GDP-L-fucose synthase is an enzyme responsible for converting GDP-4-keto-6-deoxy-D-mannose to GDP-L-fucose an important step in fucose synthesis. TSTA3 has a molecular mass of approximately 36 kDa. This protein expresses widely with significant expression in tissues like the liver which is a central site for metabolic processes.
Biological function summary

TSTA3 plays a role in fucosylation a fundamental process for the modification of glycoproteins and glycolipids. Fucosylation affects cellular recognition and signaling events. TSTA3 functions independently and as part of no known physical complex but influences several biological activities indirectly through its enzymatic product GDP-L-fucose. This product is critical in multiple cellular functions and structural carbohydrate assemblies.

Pathways

TSTA3 participates in the GDP-L-fucose biosynthesis pathway an essential route for the production of fucose necessary for fucosylation processes. This pathway ties directly to protein interactions involving glycosyltransferases such as fucosyltransferases which facilitate the transfer of fucose to glycoproteins and glycolipids. TSTA3's contribution to these pathways affects cell adhesion and immune response signaling.

TSTA3 relates mainly to cancers and congenital disorders of glycosylation. Abnormal fucosylation patterns often due to altered TSTA3 activity have been linked to various cancers impacting proteins like E-selectin which is involved in leukocyte adhesion. Additionally congenital disorders of glycosylation sometimes result from deficiencies in enzymes such as TSTA3 leading to disrupted glycan synthesis and presentation connecting to proteins such as glycoproteins with critical physiological roles.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
See full target information GFUS
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:5027 PubMed36977722

2023

Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuyuki Matsumoto,Nan Jia,Jamie Heimburg-Molinaro,Richard D Cummings

Cells 11: PubMed36231115

2022

A Novel Homozygous Founder Variant of in Two Consanguineous Saudi Families.

Applications

Unspecified application

Species

Unspecified reactive species

Mazhor Aldosary,Maysoon Alsagob,Hanan AlQudairy,Ana C González-Álvarez,Stefan T Arold,Mohammad Anas Dababo,Omar A Alharbi,Rawan Almass,AlBandary AlBakheet,Dalia AlSarar,Alya Qari,Mysoon M Al-Ansari,Monika Oláhová,Saif A Al-Shahrani,Moeenaldeen AlSayed,Dilek Colak,Robert W Taylor,Mohammed AlOwain,Namik Kaya

Bioengineered 13:5551-5563 PubMed35184647

2022

Eriodictyol suppresses the malignant progression of colorectal cancer by downregulating tissue specific transplantation antigen P35B (TSTA3) expression to restrain fucosylation.

Applications

Unspecified application

Species

Unspecified reactive species

Hua Huang,Yun He,Youran Li,Mingjia Gu,Minna Wu,Lijiang Ji

Theranostics 10:11339-11358 PubMed33042286

2020

TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Zhang,Yingzhen Gao,Xiaojuan Zhang,Min Guo,Jie Yang,Heyang Cui,Pengzhou Kong,Xia Niu,Yanghui Bi,Jing Xu,Ting Yan,Yanchun Ma,Jian Yang,Yu Qian,Fang Wang,Hongyi Li,Feng Liu,Xiaolong Cheng,Yongping Cui
View all publications
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Product promise

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