AB71498

Anti-TTC11/FIS1 antibody

(3 Reviews)

(93 Publications)

Rabbit Polyclonal TTC11/FIS1 antibody. Suitable for WB and reacts with Human samples. Cited in 93 publications.

View Alternative Names

TTC11, CGI-135, FIS1, Mitochondrial fission 1 protein, FIS1 homolog, Tetratricopeptide repeat protein 11, hFis1, TPR repeat protein 11

1 Images

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Western blot - Anti-TTC11/FIS1 antibody (AB71498)

All lanes:

Western blot - Anti-TTC11/FIS1 antibody (ab71498) at 1 µg/mL

All lanes:

Jurkat cell lysates

Predicted band size: 17 kDa

Observed band size: 17 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3491R Fis1 Polyclonal Antibody.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TTC11 also known as FIS1 is a protein that plays an important role in mitochondrial dynamics. It has a molecular weight of approximately 17 kDa. The FIS1 protein is expressed in various tissues suggesting it has a broad functional impact across different cell types. Through its structure it facilitates mitochondrial fission by interacting with other mitochondrial proteins. This process ensures proper distribution and health of mitochondria within the cell.

Biological function summary

FIS1 is critical in controlling mitochondrial size and quantity. It is part of a complex that includes proteins like DRP1 which is heavily involved in promoting the division of mitochondria. By working with DRP1 FIS1 helps maintain cellular energy levels and dynamics by ensuring that mitochondria are appropriately divided and distributed. This role impacts overall cell health and function.

Pathways

FIS1 is integral to the pathways regulating mitochondrial fission and fusion. It interacts closely within the pathway involving DRP1 and MFF both of which are critical in these processes. Furthermore FIS1's interactions in these pathways help balance mitochondrial fission and fusion maintaining cellular energy homeostasis and proper mitochondrial function.

Defects in FIS1 function relate to neurodegenerative diseases such as Alzheimer's disease and Charcot-Marie-Tooth disease. In these contexts abnormal interactions with DRP1 can lead to impaired mitochondrial dynamics contributing to disease progression. Research into these relationships continues to uncover the important role FIS1 plays in maintaining cellular health and its potential as a therapeutic target.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed : 12783892, PubMed : 12861026, PubMed : 14996942, PubMed : 23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed : 12861026, PubMed : 16118244, PubMed : 23283981, PubMed : 23530241, PubMed : 24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed : 23530241, PubMed : 24196833). Also mediates peroxisomal fission (PubMed : 16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed : 24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed : 12783892).

See full target information FIS1

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Publications (93)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:414 PubMed41039555

2025

TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyu Zhang,Shiyao Cheng,Wenxin Li,Xintian Xu,Xiaojing Huang,Zhichong Chen,Qinglang Li,Wanjing Huang,Lingxiao Zhang,Mao Ouyang

Molecular medicine reports 31: PubMed40183404

2025

α‑ketoglutarate protects against septic cardiomyopathy by improving mitochondrial mitophagy and fission.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wu,Qiong Ma,Bo-Tao Li,Shuang Shi,Gong-Chang Guan,Jun-Kui Wang,Bao-Yao Xue,Zhong-Wei Liu

The Journal of physiology 603:3725-3753 PubMed39792484

2025

Previous short-term disuse dictates muscle gene expression and physiological adaptations to subsequent resistance exercise.

Applications

Unspecified application

Species

Unspecified reactive species

Martino V Franchi,Julián Candia,Fabio Sarto,Giuseppe Sirago,Giacomo Valli,Matteo Paganini,Lisa Hartnell,Emiliana Giacomello,Luana Toniolo,Elena Monti,Leonardo Nogara,Tatiana Moro,Antonio Paoli,Marta Murgia,Lorenza Brocca,Maria Antonietta Pellegrino,Bruno Grassi,Roberto Bottinelli,Giuseppe De Vito,Luigi Ferrucci,Marco V Narici

Scientific reports 14:25979 PubMed39472629

2024

Astragaloside IV reduces mutant Ataxin-3 levels and supports mitochondrial function in Spinocerebellar Ataxia Type 3.

Applications

Unspecified application

Species

Unspecified reactive species

Yongshiou Lin,Wenling Cheng,Juichih Chang,Yuling Wu,Mingli Hsieh,Chinsan Liu

Journal of applied toxicology : JAT 44:1700-1713 PubMed38981847

2024

Berberine prevents against myocardial injury induced by acute β-adrenergic overactivation in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yalin Yang,Shuang Jiang,Yu Mu,Chilu Liu,Yanxing Han,Jiandong Jiang,Yuhong Wang

The Journal of general physiology 156: PubMed38376469

2024

Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Ricardo A Galli,Tamara C Borsboom,Charlotte Gineste,Lorenza Brocca,Maira Rossi,Darren T Hwee,Fady I Malik,Roberto Bottinelli,Julien Gondin,Maria-Antonietta Pellegrino,Josine M de Winter,Coen A C Ottenheijm

International journal of molecular sciences 24: PubMed37834400

2023

Diaphragm Fatigue in SMNΔ7 Mice and Its Molecular Determinants: An Underestimated Issue.

Applications

Unspecified application

Species

Unspecified reactive species

Francesca Cadile,Deborah Recchia,Massimiliano Ansaldo,Paola Rossi,Giorgia Rastelli,Simona Boncompagni,Lorenza Brocca,Maria Antonietta Pellegrino,Monica Canepari

Redox biology 67:102879 PubMed37716088

2023

Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Shen,Suping Ren,Yongyong Hou,Zhuo Zuo,Shengnan Liu,Zhiyuan Liu,Jingqi Fu,Huihui Wang,Bei Yang,Rui Zhao,Yanyan Chen,Masayuki Yamamoto,Yuanyuan Xu,Qiang Zhang,Jingbo Pi

Journal of lipid research 64:100413 PubMed37473919

2023

Zonal expression of StARD1 and oxidative stress in alcoholic-related liver disease.

Applications

Unspecified application

Species

Unspecified reactive species

Raquel Fucho,Estel Solsona-Vilarrasa,Sandra Torres,Susana Nuñez,Naroa Insausti-Urkia,Albert Edo,Maria Calvo,Anna Bosch,Gemma Martin,Carlos Enrich,Carmen García-Ruiz,Jose C Fernandez-Checa

Journal of ginseng research 47:408-419 PubMed37252276

2023

Ginsenoside compound K protects against cerebral ischemia/reperfusion injury via Mul1/Mfn2-mediated mitochondrial dynamics and bioenergy.

Applications

Unspecified application

Species

Unspecified reactive species

Qingxia Huang,Jing Li,Jinjin Chen,Zepeng Zhang,Peng Xu,Hongyu Qi,Zhaoqiang Chen,Jiaqi Liu,Jing Lu,Mengqi Shi,Yibin Zhang,Ying Ma,Daqing Zhao,Xiangyan Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TTC11/FIS1 antibody

Western blot - Anti-TTC11/FIS1 antibody (AB71498)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (93)

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