Anti-TTC27 antibody [EPR13653]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TTC27 also known as Tetratricopeptide Repeat Protein 27 is a protein characterized by its tetratricopeptide repeat (TPR) domains. The molecular mass of TTC27 is approximately 143 kDa. It is expressed in various tissues with particularly high levels in the brain liver and testes. These TPR domains suggest that TTC27 may be involved in protein-protein interactions functioning as a scaffold for the assembly of multiprotein complexes.

Biological function summary

TTC27 plays important roles in cellular processes. It functions as a part of larger multiprotein complexes which indicates its role in maintaining cellular homeostasis and possibly influencing signaling pathways. The protein's distribution in the brain suggests its involvement in neurological functions though detailed mechanisms remain under investigation. TTC27's interaction with other proteins points towards its potential role in regulating cellular signaling and response.

Pathways

TTC27's involvement in specific signaling pathways highlights its importance in cellular communication. Recent studies have linked TTC27 to the MAPK/ERK pathway a critical pathway for cell proliferation and differentiation. It interacts with proteins such as MEK and ERK facilitating the transmission of extracellular signals to the nucleus. Additionally TTC27 may participate in the NOD-like receptor signaling pathway further influencing immune responses and inflammation processes.

Associated diseases and disorders

TTC27's function and expression profile suggest potential links to certain conditions. Research indicates a connection between TTC27 and certain cancers where alterations in signaling pathways like MAPK/ERK could contribute to tumorigenesis. The correlation with proteins like ERK involved in cell cycle regulation highlights its role in cancer development. Furthermore TTC27's significant expression in the brain suggests possible involvement in neurological disorders drawing interest in its relationship with proteins implicated in neurodegenerative diseases.