Rabbit Polyclonal TTC3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TTC3.
IgG
Rabbit
Constituents: Whole serum
Liquid
Polyclonal
| WB | ICC/IF | |
|---|---|---|
| Human | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323).
E3 ubiquitin-protein ligase TTC3, Protein DCRR1, RING finger protein 105, RING-type E3 ubiquitin transferase TTC3, TPR repeat protein D, Tetratricopeptide repeat protein 3, TPR repeat protein 3, TTC3, DCRR1, RNF105, TPRD
Rabbit Polyclonal TTC3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TTC3.
E3 ubiquitin-protein ligase TTC3, Protein DCRR1, RING finger protein 105, RING-type E3 ubiquitin transferase TTC3, TPR repeat protein D, Tetratricopeptide repeat protein 3, TPR repeat protein 3, TTC3, DCRR1, RNF105, TPRD
IgG
Rabbit
Constituents: Whole serum
Liquid
Polyclonal
Whole antiserum
Reacts specifically with human 229 kDa TTC3 protein.
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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The TTC3 protein also known as Tetratricopeptide Repeat Domain 3 has a molecular weight of approximately 215 kDa. This protein functions as an E3 ubiquitin-protein ligase which means it plays a role in tagging proteins for degradation via the ubiquitin-proteasome system. TTC3 is widely expressed in the brain especially within neurons and is also found in other tissues such as the heart and kidneys. It contains tetratricopeptide repeats which are known for facilitating protein-protein interactions essential for its role in cellular function and signaling.
TTC3 interacts in various processes associated with cell development and stability. It is not part of a larger protein complex but operates notably in cell cycle progression and neuronal differentiation. TTC3 regulates the stability of proteins by adding ubiquitin molecules which are small regulatory proteins to target proteins. This activity is important for maintaining the cellular environment especially in tissues where precise control over protein levels is necessary.
Many cellular pathways are influenced by TTC3 including the PI3K-AKT signaling pathway which mediates several cellular processes such as growth and survival. TTC3 has connections with proteins such as AKT1 through this pathway which helps regulate cell proliferation and neurogenesis. Additionally TTC3 is involved in the stability regulation of cyclin proteins influencing the cell cycle by interacting with components of the cyclin-dependent kinase (CDK) pathway therefore affecting cell cycle checkpoints and transitions.
Evidence shows that changes in TTC3 expression have links to neurological conditions like Down syndrome and Alzheimer's disease. In these disorders altered TTC3 function affects neuronal growth and function likely through dysregulated ubiquitination processes. Additionally TTC3 interacts with proteins like DYRK1A which is also implicated in neurodegenerative conditions and Down syndrome pathophysiology. Altered TTC3 activity therefore contributes to the molecular mechanisms driving these diseases suggesting its potential as a therapeutic target.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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