Anti-TTC36 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TTC36 also known as tetratricopeptide repeat domain 36 is a protein comprised of approximately 275 amino acids resulting in a mass of about 31 kDa. This protein predominantly localizes in the cytoplasm. TTC36 shows expression in various tissues including the brain and liver suggesting its involvement in key cellular activities. The structure includes multiple tetratricopeptide repeat (TPR) motifs that are known for mediating protein-protein interactions which can have significant implications for cellular processes.

Biological function summary

TTC36 plays a role in modulating cellular signaling pathways. It interacts with other proteins to influence cell growth and division. Its presence in the cytoplasm suggests that it could potentially form part of a larger protein complex facilitating communication between different signaling networks. This role may not be direct as it often mediates through interaction with other signaling proteins. These interactions help the cell maintain its regulatory mechanisms and ensure proper cellular responses to signaling cues.

Pathways

TTC36 associates with key cellular processes like the MAPK and NF-kB signaling pathways. These pathways involve important cellular activities such as proliferation differentiation and apoptosis. In the MAPK pathway TTC36 may interact with proteins like ERK influencing the transmission of extracellular signals into the cell. For the NF-kB signaling pathway interactions with proteins such as IKK can modulate the inflammatory responses. These connections place TTC36 in a strategic position to affect major cellular responses and regulate diverse biological functions.

Associated diseases and disorders

TTC36 shows associations with certain cancers and neurodegenerative disorders. Its involvement in cancers is possibly due to its role in the MAPK pathway where dysregulation can lead to uncontrolled cell growth. This protein may also interact with growth factor receptors contributing to tumorigenesis. In neurodegenerative disorders TTC36’s connection to inflammation via the NF-kB pathway might influence disease progression as chronic inflammation is a known factor in diseases like Alzheimer's disease. These associations suggest that further understanding of TTC36’s role could provide insights into therapeutic strategies for both cancer and neurodegenerative diseases.