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AB122507

Anti-TTC36 antibody

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(4 Publications)

Rabbit Polyclonal TTC36 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TTC36 aa 1-100.

View Alternative Names

HBP21, TTC36, Tetratricopeptide repeat protein 36, TPR repeat protein 36, HSP70-binding protein 21

2 Images
Western blot - Anti-TTC36 antibody (AB122507)
  • WB

Unknown

Western blot - Anti-TTC36 antibody (AB122507)

All lanes:

Western blot - Anti-TTC36 antibody (ab122507) at 0.4 µg/mL

All lanes:

Human liver lysate

Predicted band size: 21 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTC36 antibody (AB122507)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTC36 antibody (AB122507)

ab122507 at 1/900 dilution staining TTC36 in Paraffin-embedded Human Liver tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TTC36 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

A6NLP5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/250 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/250 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TTC36 also known as tetratricopeptide repeat domain 36 is a protein comprised of approximately 275 amino acids resulting in a mass of about 31 kDa. This protein predominantly localizes in the cytoplasm. TTC36 shows expression in various tissues including the brain and liver suggesting its involvement in key cellular activities. The structure includes multiple tetratricopeptide repeat (TPR) motifs that are known for mediating protein-protein interactions which can have significant implications for cellular processes.
Biological function summary

TTC36 plays a role in modulating cellular signaling pathways. It interacts with other proteins to influence cell growth and division. Its presence in the cytoplasm suggests that it could potentially form part of a larger protein complex facilitating communication between different signaling networks. This role may not be direct as it often mediates through interaction with other signaling proteins. These interactions help the cell maintain its regulatory mechanisms and ensure proper cellular responses to signaling cues.

Pathways

TTC36 associates with key cellular processes like the MAPK and NF-kB signaling pathways. These pathways involve important cellular activities such as proliferation differentiation and apoptosis. In the MAPK pathway TTC36 may interact with proteins like ERK influencing the transmission of extracellular signals into the cell. For the NF-kB signaling pathway interactions with proteins such as IKK can modulate the inflammatory responses. These connections place TTC36 in a strategic position to affect major cellular responses and regulate diverse biological functions.

TTC36 shows associations with certain cancers and neurodegenerative disorders. Its involvement in cancers is possibly due to its role in the MAPK pathway where dysregulation can lead to uncontrolled cell growth. This protein may also interact with growth factor receptors contributing to tumorigenesis. In neurodegenerative disorders TTC36’s connection to inflammation via the NF-kB pathway might influence disease progression as chronic inflammation is a known factor in diseases like Alzheimer's disease. These associations suggest that further understanding of TTC36’s role could provide insights into therapeutic strategies for both cancer and neurodegenerative diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TTC36
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Mediators of inflammation 2025:9021628 PubMed40757051

2025

HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Na An,Mingzhi Xu,Ruman Chen,Cuijuan Wang,Yafei Bai

Clinical epigenetics 15:73 PubMed37120619

2023

Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Agustin Sgro,Joseph Cursons,Charlene Waryah,Eleanor A Woodward,Momeneh Foroutan,Ruqian Lyu,George C T Yeoh,Peter J Leedman,Pilar Blancafort

Frontiers in pharmacology 12:634115 PubMed34163351

2021

Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Shaorong Li,Hua Jin,Guangyong Sun,Chunmei Zhang,Jinsong Wang,Hufeng Xu,Dong Zhang,Songlin Wang

Journal of Cancer 12:2598-2609 PubMed33854620

2021

TTC36 inactivation induce malignant properties via Wnt-β-catenin pathway in gastric carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Song,Xiaonong Guo,Fei Zhao,Wei Wang,Zhifang Zhao,Long Jin,Chengli Wu,Jibin Yao,Zhongren Ma
View all publications
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