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AB122421

Anti-TTC37 antibody

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(2 Publications)

Rabbit Polyclonal TTC37 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SKIC3 aa 450-600.

View Alternative Names

KIAA0372, TTC37, SKIC3, Superkiller complex protein 3, Ski3, Tetratricopeptide repeat protein 37, Tricho-hepatic-enteric syndrome protein, TPR repeat protein 37, Thespin

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-TTC37 antibody (AB122421)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TTC37 antibody (AB122421)

Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab122421 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTC37 antibody (AB122421)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTC37 antibody (AB122421)

ab122421 at 1/35 dilution staining TTC37 in Paraffin-embedded Human stomach tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SKIC3 aa 450-600. The exact immunogen used to generate this antibody is proprietary information.

Q6PGP7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TTC37 protein also known as Tetratricopeptide Repeat Domain 37 is an important element in the cellular machinery of humans. It is a 1562 amino acid protein with a molecular weight of approximately 178 kDa. The TTC37 protein expresses mainly in the cytoplasm and is found in various tissues including the brain liver and gastrointestinal tract. It contains several tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions indicating its role in cellular functions related to these processes.
Biological function summary

TTC37 is involved in managing processes essential for maintaining cellular homeostasis. It is part of the Ski complex which is involved in the regulation of RNA metabolism. TTC37's role in the Ski complex is to assist in the exosome-mediated RNA decay pathway contributing to the quality control of RNA within the cell. This regulation ensures the degradation of defective or surplus RNA molecules which is fundamental for correct gene expression and cellular function.

Pathways

The exosome-mediated decay pathway represents one of the key pathways in which TTC37 operates. Another significant pathway is the nonsense-mediated decay (NMD) pathway where TTC37 interacts with proteins like SKIV2L involved in eliminating aberrant mRNA transcripts. These pathways are vital for cellular regulation and preventing the buildup of faulty RNA that could disrupt normal cell function. By engaging with these pathways TTC37 helps preserve the balance of RNA within the cell ensuring efficient communication and processing essential for cell survival and adaptation.

TTC37 mutations have been associated with a rare genetic disease known as Trichohepatoenteric syndrome (THES). This condition affects multiple systems including the skin liver and intestines and is characterized by growth retardation and immunodeficiency. TTC37's relation to this syndrome highlights its importance in maintaining cellular and physiological health. Additionally proteins such as SKIV2L which work alongside TTC37 are similarly implicated in conditions with overlapping clinical features emphasizing the shared pathways and interactions within these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed : 16024656, PubMed : 32006463, PubMed : 35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed : 32006463, PubMed : 35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed : 32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed : 16024656).
See full target information SKIC3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature 638:1095-1103 PubMed39910291

2025

Synthetic lethality of mRNA quality control complexes in cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Vivian Prindle,Adam E Richardson,Kimberly R Sher,Sarah Kongpachith,Kaitlin Kentala,Sakina Petiwala,Dong Cheng,Deborah Widomski,Phuong Le,Maricel Torrent,Anlu Chen,Stephen Walker,Marianne B Palczewski,Diya Mitra,Vlasios Manaves,Xu Shi,Charles Lu,Stephanie Sandoval,Zoltan Dezso,F Gregory Buchanan,Daniel Verduzco,Brian Bierie,Jonathan A Meulbroek,William N Pappano,Joshua P Plotnik

Nature immunology 15:839-45 PubMed25064072

2014

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Sterling C Eckard,Gillian I Rice,Alexandre Fabre,Catherine Badens,Elizabeth E Gray,Jane L Hartley,Yanick J Crow,Daniel B Stetson
View all publications
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Product promise

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