Anti-TTC4 antibody [EPR13381-76]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TTC4 also known as Tetratricopeptide Repeat Protein 4 has a molecular mass of approximately 44 kDa. It functions as a molecular chaperone assisting in the folding and stability of other proteins. TTC4 contains tetratricopeptide repeat (TPR) motifs which play a role in protein-protein interactions. These motifs enable TTC4 to interact with various cellular proteins. It is expressed widely in human tissues with higher levels observed in the heart brain and testis.

Biological function summary

The tetratricopeptide repeats in TTC4 facilitate its role as a part of multiprotein complexes. This protein takes part in regulating important cellular processes like cell cycle control and stress response. TTC4 assists in stabilizing proteins during cellular stress ensuring proper cellular function under adverse conditions. It may also interact with heat shock proteins (HSPs) contributing to protein homeostasis in cells.

Pathways

This protein is involved in important cellular processes including the signal transduction pathways and protein quality control pathways. TTC4 is notably involved in the chaperone-mediated autophagy pathway where it regulates the turnover and recycling of damaged proteins. It relates to proteins such as Hsp70 which are central to cellular stress response mechanisms. This relationship plays an important role in maintaining protein stability and cellular function.

Associated diseases and disorders

TTC4's role in maintaining cellular protein stability links it to conditions caused by protein misfolding. Misregulation in its function may contribute to neurodegenerative diseases such as Alzheimer's disease where excessive protein aggregation occurs. Additionally TTC4 interacts with proteins like Tau which are important in the pathogenesis of Alzheimer's. Aberrations in TTC4 might also influence cancer progression due to its involvement in cell cycle regulation linking it to proteins such as p53 known for its tumor suppressor role.