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AB193361

Anti-TTC7B antibody [EPR15995]

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(1 Publication)

Rabbit Recombinant Monoclonal TTC7B antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

TTC7L1, TTC7B, Tetratricopeptide repeat protein 7B, TPR repeat protein 7B, Tetratricopeptide repeat protein 7-like-1, TPR repeat protein 7-like-1

2 Images
Immunoprecipitation - Anti-TTC7B antibody [EPR15995] (AB193361)
  • IP

Supplier Data

Immunoprecipitation - Anti-TTC7B antibody [EPR15995] (AB193361)

Western blot analysis of TTC7B immunoprecipitated from K562 cell lysate using ab193361 at 1/60 dilution.

Secondary antibody : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution.

Blocking/Dilution buffer : 5% NFDM/TBST.

All lanes:

Immunoprecipitation - Anti-TTC7B antibody [EPR15995] (ab193361)

Predicted band size: 94 kDa

false

Western blot - Anti-TTC7B antibody [EPR15995] (AB193361)
  • WB

Supplier Data

Western blot - Anti-TTC7B antibody [EPR15995] (AB193361)

Blocking/Dilution buffer : 5% NFDM/TBST.

All lanes:

Western blot - Anti-TTC7B antibody [EPR15995] (ab193361) at 1/1000 dilution

Lane 1:

K562 cell lysate at 20 µg

Lane 2:

Human fetal brain lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 94 kDa

Observed band size: 94 kDa

false

  • Carrier free

    Anti-TTC7B antibody [EPR15995] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR15995

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/60", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TTC7B also known as Tetratricopeptide Repeat Domain 7B is a protein with a mass of approximately 114 kDa. Mechanically it contains several tetratricopeptide repeat (TPR) motifs that facilitate protein-protein interactions. This protein is expressed in many tissues with notable levels in the liver and kidney. Its role is to help with various cellular processes likely through binding with other proteins to form functional complexes.
Biological function summary

TTC7B contributes to cellular functions through its involvement in the phosphatidylinositol-4 kinase pathway. This pathway is important for the regulation of cell signaling and membrane trafficking. TTC7B is part of the GOLPH3/TTC7B complex which maintains proper Golgi function and morphology an essential aspect for vesicular transport and signal transduction.

Pathways

The phosphatidylinositol signaling and inositol phosphate metabolism pathways require TTC7B's participation. These pathways are critical for various cellular processes including cell growth survival and communication. TTC7B interfaces with proteins such as PI4KA and FAM126A which are important for phosphatidylinositol 4-phosphate synthesis impacting overall pathway functionality.

Improper TTC7B function can associate with Golgi function-related disorders. Conditions such as Lenz-Majewski hyperostotic dwarfism have connections to the dysregulation of pathways involving TTC7B. In these contexts proteins like PI4KA also interact in the disease mechanism illustrating TTC7B's significance in maintaining cellular and physiological balance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed : 26571211).
See full target information TTC7B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature genetics 57:680-693 PubMed40069506

2025

Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Long Liang,Xinwei Kuang,Yi He,Lin Zhu,Poyee Lau,Xin Li,Dingan Luo,Lan Gong,Wenbin Zhou,Fanglin Zhang,Xiaowei Liang,Zhuofeng Li,Bin Hu,Dandan Liu,Tao Ding,Hui Li,Shuang Zhao,Juan Su,Mien-Chie Hung,Jing Liu,Hong Liu,Xiang Chen
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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