Rabbit Polyclonal TTPA/TPP1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human TTPA aa 200 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | IHC-P | ICC/IF | |
---|---|---|---|
Human | Tested | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity).
TPP1, TTPA, TPP1, Alpha-tocopherol transfer protein, Alpha-TTP
Rabbit Polyclonal TTPA/TPP1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human TTPA aa 200 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
TTPA also known as tocopherol (alpha) transfer protein and TPP1 is a protein with a mass of approximately 32 kDa. The protein binds to alpha-tocopherol a type of vitamin E and facilitates its transfer to cellular membranes. TTPA is mainly expressed in the liver but also found in smaller amounts in the brain lungs and other tissues. The protein ensures the efficient distribution of vitamin E throughout the body playing a significant role in maintaining cellular health.
In many organisms TTPA acts as an important transporter of vitamin E helping protect cells against oxidative damage by delivering it to sites where it acts as an antioxidant. While not formally part of a recognized complex the protein interacts with cellular membranes as it transfers alpha-tocopherol. The function supports cell protection and injury prevention by ensuring an adequate supply of this essential vitamin.
Vitamin E's movement within the body is directly influenced by TTPA's activity placing the protein within the tocopherol transport and metabolism pathways. The interaction with other antioxidant systems like the glutathione pathway highlights TTPA's importance in cellular redox homeostasis. TTPA-related proteins such as vitamin E-binding proteins modulate this transport and influence overall oxidative stress responses.
Mutations in the TTPA gene can lead to a rare neurodegenerative disorder known as ataxia with vitamin E deficiency (AVED). This condition highlights the critical need for functional TTPA in neurological health. Additionally research has linked TTPA to liver-related conditions where an association is found with lower levels of vitamin E and liver damage emphasizing its role as a protector of liver tissues. Understanding these connections helps target TTPA-related pathways and proteins such as APOB for potential therapeutic interventions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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12% SDS PAGE
All lanes: Western blot - Anti-TTPA/TPP1 antibody (ab155323) at 1/1000 dilution
All lanes: IMR32 whole cell lysate at 30 µg
Predicted band size: 32 kDa
Immunofluorescence analysis of methanol-fixed MCF7 cells labeling TTPA/TPP1 using ab155323 at 1/500 dilution. Lower image shows cells co-stained with Hoechst 33342.
Immunohistochemical analysis of paraffin-embedded Human gastric carcinoma tissue labeling TTPA/TPP1 with ab155323 at 1/500 dilution
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