Anti-TUBG1 antibody [EPR8449] - Centrosome Marker

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TUBG1 also known as gamma-tubulin plays an important role in the nucleation of microtubules. It acts as a vital component in the formation of microtubule-organizing centers such as centrosomes and spindle pole bodies. Gamma-tubulin typically has a molecular mass of around 48 kDa. Expression of TUBG1 occurs in various tissues with notable presence in brain and testes reflecting its importance in cells undergoing rapid division and developmental processes.

Biological function summary

Gamma-tubulin forms part of the gamma-tubulin ring complex which facilitates the initiation of microtubule assembly. This protein complex binds to microtubule minus ends and provides a template assisting in polymerization. Through this action TUBG1 indirectly influences cell shape motility and division. The gamma-tubulin ring complex therefore ensures proper mitotic spindle formation essential for accurate chromosomal segregation during cell division.

Pathways

Multiple cellular processes such as mitotic spindle assembly and cell cycle progression rely on the function of TUBG1. This protein integrates into the spindle assembly checkpoint pathway ensuring chromosomes attach correctly to spindle fibers before segregation. It's also implicated in the microtubule nucleation pathway working alongside other proteins like TUBGCP2 and NEDD1 to maintain microtubule dynamics and cellular organization.

Associated diseases and disorders

Mutations or dysregulation of TUBG1 links to cancer and certain neurological conditions. Alterations in TUBG1 expression can contribute to tumor development given its role in cell cycle control and division. Moreover TUBG1 mutations associate with brain malformations such as lissencephaly where gamma-tubulin interacts with proteins like LIS1 involved in neuronal migration. Understanding TUBG1's contributions to both normal cellular processes and disease states can offer insights into new therapeutic approaches.