AB70182

Anti-TUSC2/FUS1 antibody

Name: Anti-TUSC2/FUS1 antibody (ab70182) | Abcam
Brand: Abcam Limited
SKU: AB70182

Be the first to review this product! Submit a review

(6 Publications)

Rabbit Polyclonal TUSC2/FUS1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TUSC2.

View Alternative Names

C3orf11, FUS1, LGCC, PDAP2, TUSC2, Tumor suppressor candidate 2, Fusion 1 protein, PDGFA-associated protein 2, Fus-1 protein

1 Images

Unknown

Western blot - Anti-TUSC2/FUS1 antibody (AB70182)

All lanes:

Western blot - Anti-TUSC2/FUS1 antibody (ab70182) at 1/500 dilution

Lane 1:

HeLa cell extract at 5 µg

Lane 2:

HeLa cell extract at 5 µg with immunising peptide

Predicted band size: 12 kDa

Observed band size: <19 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human TUSC2. The exact immunogen used to generate this antibody is proprietary information.

O75896

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TUSC2/FUS1 protein also known by its alternate name TUSC2 plays an essential role in cellular processes. It has a molecular mass of approximately 12 kDa and is found throughout various tissues but is predominantly expressed in the mitochondria. TUSC2 localizes to chromosomal region 3p21.3 which often undergoes deletions in lung cancer. Its expression can be lost or significantly reduced in certain cancers indicating its potential tumor-suppressive role.

Biological function summary

TUSC2 participates in several critical cellular functions and is part of a larger complex with other proteins. It influences cell proliferation apoptosis and signal transduction pathways. TUSC2 functions as a tumor suppressor helping to regulate cell growth and prevent malignant transformation. It acts in apoptosis induction and cell cycle control often by modulating reactive oxygen species (ROS) levels within cells.

Pathways

TUSC2 is instrumental in regulating several cellular pathways. It is a participant in the PI3K/Akt and MAPK pathways which are vital for cell survival growth and metabolism. TUSC2 interacts with proteins like Akt and p53 playing an important role in maintaining cellular homeostasis and preventing aberrant cell division. These interactions help TUSC2 modulate apoptosis and promote cell-cycle arrest under stressful conditions.

TUSC2 has a notable connection to cancer particularly lung cancer and mesothelioma. In these diseases TUSC2 expression often decreases due to chromosomal deletions. The protein's interaction with other tumor suppressors such as p53 and PTEN influences tumorigenesis by disrupting normal signaling pathways leading to uncontrolled cell proliferation. Restoring TUSC2 function or expression could open avenues for therapeutic interventions in cancer treatment.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

See full target information TUSC2

style

left-column

Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cancer letters 531:124-135 PubMed35167936

2022

NEDD4 degrades TUSC2 to promote glioblastoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Tadas K Rimkus,Austin B Arrigo,Dongqin Zhu,Richard L Carpenter,Sherona Sirkisoon,Daniel Doheny,Angelina T Regua,Grace L Wong,Sara Manore,Calvin Wagner,Hui-Kuan Lin,Guangxu Jin,Jimmy Ruiz,Michael Chan,Waldemar Debinski,Hui-Wen Lo

Cellular and molecular neurobiology 42:2245-2256 PubMed33993369

2021

Circ-EGFR Functions as an Inhibitory Factor in the Malignant Progression of Glioma by Regulating the miR-183-5p/TUSC2 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Qingdong Guo,Jun Guo,Wei Liu,Shijie Hu,Xuean Hu,Qianliang Wang,Xiaofan Jiang

Scientific reports 9:12718 PubMed31481748

2019

MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression.

Applications

Unspecified application

Species

Unspecified reactive species

Srikanth Nama,Manish Muhuri,Federica Di Pascale,Shan Quah,Luay Aswad,Melissa Fullwood,Prabha Sampath

BMC cancer 18:894 PubMed30219035

2018

TUSC2P suppresses the tumor function of esophageal squamous cell carcinoma by regulating TUSC2 expression and correlates with disease prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Fengqiong Liu,Ruijie Gong,Baochang He,Fa Chen,Zhijian Hu

PloS one 10:e0137887 PubMed26367773

2015

Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression.

Applications

Species

Human

Kumiko Yamamoto,Sachio Ito,Hiroko Hanafusa,Kenji Shimizu,Mamoru Ouchida

Nature communications 5:2914 PubMed24394498

2014

The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs.

Applications

Species

Mouse

Zina Jeyapalan Rutnam,William W Du,Weining Yang,Xiangling Yang,Burton B Yang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TUSC2/FUS1 antibody

Western blot - Anti-TUSC2/FUS1 antibody (AB70182)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise