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AB64803

Anti-TUSC5 antibody

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(1 Publication)

Rabbit Polyclonal TUSC5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TRARG1.

View Alternative Names

IFITMD3, LOST1, TUSC5, TRARG1, Trafficking regulator of GLUT4 1, Dispanin subfamily B member 1, Interferon-induced transmembrane domain-containing protein D3, Protein located at seventeen-p-thirteen point three 1, Tumor suppressor candidate 5, DSPB1

1 Images
Western blot - Anti-TUSC5 antibody (AB64803)
  • WB

Unknown

Western blot - Anti-TUSC5 antibody (AB64803)

All lanes:

Western blot - Anti-TUSC5 antibody (ab64803) at 1/500 dilution

Lane 1:

Extracts from LOVO cells at 5 µg

Lane 2:

Extracts from LOVO cells plus peptide at 10µg at 5 µg

Predicted band size: 19 kDa

Observed band size: 22 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human TRARG1. The exact immunogen used to generate this antibody is proprietary information.

Q8IXB3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TUSC5 protein also known as Tumor Suppressor Candidate 5 plays specific mechanical roles in cellular function. It has a molecular mass of approximately 30 kDa. TUSC5 is expressed mostly in adipose tissue and peripheral nervous system tissues. Its structure includes four transmembrane domains making it a component of cell membranes where it can interact with other membrane-associated proteins.
Biological function summary

The TUSC5 protein interacts with cellular processes related to metabolism and cell growth regulation. While it is not part of a large defined protein complex its function influences energy homeostasis within adipocytes. TUSC5 regulates expression of genes involved in lipid metabolism providing key adjustments to adipocyte function. This regulation aids in the adaptation to changes in energy balance and nutrient availability within the organism.

Pathways

The TUSC5 protein participates in both lipid metabolism and insulin signaling pathways. It influences how adipocytes respond to insulin linking to proteins such as AKT1 which plays a prominent role in glucose uptake and metabolism. Insulin-mediated pathways which are critical to energy storage and release in adipose tissue also benefit from the regulatory influence of TUSC5 ensuring proper cellular response to hormonal signals.

TUSC5 impacts conditions like obesity and type 2 diabetes. These metabolic disorders result from an imbalance in energy intake and expenditure where TUSC5 plays a role in modulating fat storage and lipid metabolism. Research shows that aberrant expression of the TUSC5 protein correlates with disrupted metabolic homeostasis in adipose tissues. The protein is further linked to disorders through its relationship with AKT1 which is essential for maintaining normal insulin function and glucose homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.
See full target information TRARG1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 10:e0130543 PubMed26110767

2015

EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Desamparados Roda,Josefa Castillo,Marcelino Telechea-Fernández,Anabel Gil,Gerardo López-Rodas,Luís Franco,Patricia González-Rodríguez,Susana Roselló,J Alejandro Pérez-Fidalgo,Elena R García-Trevijano,Andrés Cervantes,Rosa Zaragozá
View all publications
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Product promise

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