JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB183890

Anti-TWSG1/TSG antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal TWSG1/TSG antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TWSG1 aa 1-250.

View Alternative Names

TSG, PSEC0250, TWSG1, Twisted gastrulation protein homolog 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TWSG1/TSG antibody (AB183890)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TWSG1/TSG antibody (AB183890)

Immunohistochemical analysis of paraffin-embedded mouse prostate labeling TWSG1/TSG using ab183890 at a 1/500 dilution.

Western blot - Anti-TWSG1/TSG antibody (AB183890)
  • WB

Supplier Data

Western blot - Anti-TWSG1/TSG antibody (AB183890)

All lanes:

Western blot - Anti-TWSG1/TSG antibody (ab183890) at 1/1000 dilution

All lanes:

A549 whole cell lysate/extract at 30 µg

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TWSG1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9GZX9

style
left-column

Complementary Products

Primary Antibodies

AB125011

Anti-TSG101 antibody [EPR7130(B)]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry - Anti-TSG101 antibody [EPR7130(B)] (AB125011)

  • 4
  • 10
Primary Antibodies

AB236630

Anti-CD9 antibody [EPR23105-121]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD9 antibody [EPR23105-121] (AB236630)

  • 5
  • 4
Primary Antibodies

AB134045

Anti-CD63 antibody [EPR5702] - Late Endosome Marker

20ul selling size|RabMAb|Recombinant|KO Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD63 antibody [EPR5702] - Late Endosome Marker (AB134045)

  • 3
  • 6
Primary Antibodies

AB181606

Anti-Hsp70 antibody [EPR16892]

20ul selling size|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Hsp70 antibody [EPR16892] (AB181606)

  • 4
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TWSG1 also known as TSG or Twisted Gastrulation Protein Homolog 1 is a secreted protein involved in the modulation of signaling pathways. It has a molecular mass of approximately 24 kDa. TWSG1 is expressed in a variety of tissues including the brain heart and skeletal muscle. This protein interacts directly with other molecules to influence cellular communication and development processes.
Biological function summary

TWSG1 interacts with members of the bone morphogenetic protein (BMP) family modulating their signaling activity. TWSG1 functions as part of a complex with other extracellular matrix proteins which helps regulate the availability and activity of BMPs. This regulation is essential during early embryonic development and tissue differentiation. By fine-tuning BMP signaling TWSG1 plays a significant role in proper developmental processes.

Pathways

TWSG1 is integral in the BMP signaling and TGF-beta pathways. These pathways are influential in promoting cell growth differentiation and apoptosis. In the BMP signaling pathway TWSG1 interacts with Noggin and Chordin. These interactions ensure balanced signaling which is necessary for correct tissue formation and organogenesis. The role of TWSG1 in regulating TGF-beta pathways further highlights its involvement in controlling cellular responses to environmental stimuli.

TWSG1 is linked to craniofacial malformations and cancer. Disruptions in BMP signaling where TWSG1 plays a regulatory role can lead to improper craniofacial development resulting in congenital deformities. Additionally aberrant expression of TWSG1 affects tumorigenic processes contributing to certain cancers. For example TWSG1 is connected to the overexpression of BMPs and TGF-beta proteins which can promote tumor growth and metastasis in various cancers.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
See full target information TWSG1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell insight 2:100112 PubMed37388553

2023

The CHCHD2/Sirt1 corepressors involve in G9a-mediated regulation of RNase H1 expression to control R-loop.

Applications

Unspecified application

Species

Unspecified reactive species

Le Li,Yequn Wu,Kui Dai,Qing Wang,Shiqi Ye,Qipeng Shi,Zhenfei Chen,Yi-Chun Huang,Weiwei Zhao,Lijia Li
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com