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AB203302

Anti-TXLNB antibody

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(1 Publication)

Rabbit Polyclonal TXLNB antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TXLNB aa 350-450 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

C6orf198, MDP77, TXLNB, Beta-taxilin, Muscle-derived protein 77, hMDP77

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXLNB antibody (AB203302)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXLNB antibody (AB203302)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse embryo muscle tissue labeling TXLNB with ab203302 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Western blot - Anti-TXLNB antibody (AB203302)
  • WB

Supplier Data

Western blot - Anti-TXLNB antibody (AB203302)

12% SDS PAGE gel

All lanes:

Western blot - Anti-TXLNB antibody (ab203302) at 1/200 dilution

All lanes:

Mouse skeletal muscle lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/3000 dilution

Predicted band size: 77 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human TXLNB aa 350-450 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8N3L3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>When using a fluorescent probe the recommended dilution is 1/50 – 1/200.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TXLNB also known as Taxilin beta is a protein involved in vesicle trafficking. It is a protein with a mass of approximately 55 kDa. TXLNB localizes in both the cytoplasm and the membrane compartments of cells. Expression of TXLNB is evident in various tissues with especially high levels observed in the nervous system and reproductive tissues. The protein helps in the transportation and targeting of intracellular vesicles facilitating cellular operations that depend on precise vesicle movements.
Biological function summary

The action of TXLNB influences a range of cellular processes. It acts as a component of the membrane trafficking system interacting with syntaxin family members to assist in positioning and fusing vesicles. The protein is part of a larger complex involved in ensuring precise membrane fusion events necessary for transferring cellular materials. This function is essential for maintaining the cellular environment and proper functioning of protein sorting mechanisms.

Pathways

TXLNB plays significant roles in exocytotic pathways and intracellular transport mechanisms. It is intricately involved in the SNARE complex an important player in vesicle fusion activities. TXLNB collaborates with other proteins like syntaxins and synaptotagmins within these pathways regulating the precise events of vesicular transport. These interactions ensure that cellular materials are distributed appropriately supporting various physiological functions.

TXLNB has connections to conditions like neurodegenerative diseases and certain reproductive system disorders. Aberrations in TXLNB expression or function may disrupt vesicular transport contributing to the pathogenesis of diseases such as Alzheimer’s disease where efficient cellular transport is compromised. Additionally its interaction with proteins like syntaxin 1A relates to the synaptic dysfunction and protein trafficking issues characteristic of these disorders. Therapeutic strategies targeting TXLNB and its partners hold potential for treating related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.
See full target information TXLNB
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic translation 49:96-106 PubMed39430133

2024

CD73 alleviates osteoarthritis by maintaining anabolism and suppressing catabolism of chondrocytes extracellular matrix.

Applications

Unspecified application

Species

Unspecified reactive species

Hu Guo,Zhongyang Lv,Maochun Wang,Weitong Li,Ya Xie,Zizheng Liu,Fufei Chen,Ruiyang Jiang,Yuan Liu,Rui Wu,Jiawei Li,Ziying Sun,Guihua Tan,Dongquan Shi
View all publications
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Product promise

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