AB174276

Anti-TXNDC13/TMX4 antibody [EPR12321]

RabMAb
Recombinant
What is this?

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(1 Publication)

Rabbit Recombinant Monoclonal TXNDC13/TMX4 antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KIAA1162, TXNDC13, PSEC0095, UNQ475/PRO938, TMX4, Thioredoxin-related transmembrane protein 4, Thioredoxin domain-containing protein 13

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-TXNDC13/TMX4 antibody [EPR12321] (AB174276)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TXNDC13/TMX4 antibody [EPR12321] (AB174276)

Immunofluorescent analysis of A375 cells labeling TXNDC13/TMX4 with ab174276 at 1/50 dilution (red). DAPI nuclear staining (blue).

Supplier Data

Immunoprecipitation - Anti-TXNDC13/TMX4 antibody [EPR12321] (AB174276)

Western blot analysis on immunoprecipitation pellet from (1) A375 cell lysate or (2) 1X PBS (negative control) using ab174276 at 1/10 dilution and HRP-conjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG.

All lanes:

Immunoprecipitation - Anti-TXNDC13/TMX4 antibody [EPR12321] (ab174276)

Predicted band size: 39 kDa

false

Supplier Data

Western blot - Anti-TXNDC13/TMX4 antibody [EPR12321] (AB174276)

All lanes:

Western blot - Anti-TXNDC13/TMX4 antibody [EPR12321] (ab174276) at 1/1000 dilution

Lane 1:

A375 cell lysate at 10 µg

Lane 2:

293T cell lysate at 10 µg

Lane 3:

SH-SY5Y cell lysate at 10 µg

Lane 4:

U87-MG cell lysate at 10 µg

Predicted band size: 39 kDa

false

Carrier free

Anti-TXNDC13/TMX4 antibody [EPR12321] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12321

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IP, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/100", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TXNDC13 also known as TMX4 is a protein involved in redox reactions functioning as a thioredoxin-like enzyme. This protein has a molecular mass of approximately 45 kDa and is located primarily in the endoplasmic reticulum. Expression of TXNDC13/TMX4 is observed in various tissues but it is notably high in ones where protein folding and secretion activities are extensive. The involvement of TXNDC13/TMX4 in protein disulfide isomerization centers around its ability to catalyze the formation and breaking of disulfide bonds in proteins which is essential for proper protein folding and maturation.

Biological function summary

The role of thioredoxin-like proteins such as TXNDC13/TMX4 is critical in maintaining cellular redox balance and participating in oxidative stress response. TXNDC13/TMX4 does not appear to be a part of a larger protein complex but operates by interacting directly with other proteins as a chaperone. It helps in the formation of disulfide bonds and alleviates misfolded proteins ensuring correct protein structure and function. This activity is particularly significant in cells with high secretory demands.

Pathways

TXNDC13/TMX4 is involved in pathways governing cellular redox homeostasis and the unfolded protein response. It acts in the thioredoxin pathway an important regulator of the cellular redox environment. The protein's functioning relates to other proteins such as PDI which are key elements in the protein-folding machinery within the endoplasmic reticulum. TXNDC13/TMX4 works closely with such proteins to manage oxidation and reduction reactions essential for controlling cellular oxidative stress levels.

TXNDC13/TMX4 links with conditions involving oxidative stress and protein misfolding such as neurodegenerative diseases and certain cancers. Dysregulation in this protein's activity can contribute to the aggregation of misfolded proteins exacerbating disorders like neurodegeneration. It may also have a role in tumor biology where altered redox states are often observed. The protein is connected to others like TXN which also influence cellular responses to oxidative stress further implicating it in the pathological mechanisms of these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information TMX4

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in medicine 12:1529495 PubMed40421300

2025

Proteomic insights into COPD pathogenesis and therapeutic targets: a causal analysis of circulating proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Min Luo,Ying Tang,Jing Qiu,Kai Yang,WenJing Dai,EnRong Fang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TXNDC13/TMX4 antibody [EPR12321]

Immunocytochemistry/ Immunofluorescence - Anti-TXNDC13/TMX4 antibody [EPR12321] (AB174276)

Immunoprecipitation - Anti-TXNDC13/TMX4 antibody [EPR12321] (AB174276)

Western blot - Anti-TXNDC13/TMX4 antibody [EPR12321] (AB174276)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise