AB227623

Anti-TXNDC5 antibody

Name: Anti-TXNDC5 antibody (ab227623) | Abcam
Brand: Abcam Limited
SKU: AB227623

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(1 Publication)

Rabbit Polyclonal TXNDC5 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TXNDC5.

View Alternative Names

TLP46, UNQ364/PRO700, TXNDC5, Thioredoxin domain-containing protein 5, Endoplasmic reticulum resident protein 46, Thioredoxin-like protein p46, ER protein 46, ERp46

2 Images

Supplier Data

Western blot - Anti-TXNDC5 antibody (AB227623)

10% SDS-PAGE gel.

All lanes:

Western blot - Anti-TXNDC5 antibody (ab227623) at 1/1000 dilution

Lane 1:

Huh-7 whole cell extract at 30 µg

Lane 2:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell extract at 30 µg

Predicted band size: 48 kDa

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Lab

Western blot - Anti-TXNDC5 antibody (AB227623)

All lanes:

Western blot - Anti-TXNDC5 antibody (ab227623) at 1/1000 dilution

Lane 1:

WT 293T cell extracts at 30 µg

Lane 2:

TXNDC5 Knockout 293T cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 48 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human TXNDC5. The exact immunogen used to generate this antibody is proprietary information.

Q8NBS9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TXNDC5 also known as Thioredoxin Domain-Containing Protein 5 is an endoplasmic reticulum-resident protein with a molecular mass of approximately 48 kDa. This protein functions as a disulfide isomerase assisting in the formation and rearrangement of disulfide bonds in newly synthesized proteins. Researchers note its high expression in tissues such as the liver lung and heart where protein folding demands are significant. Due to its involvement in protein folding TXNDC5 maintains cellular homeostasis and assists in proper protein assembly.

Biological function summary

TXNDC5 contributes to the oxidative folding of proteins within the endoplasmic reticulum. The protein does not act alone but as part of a larger complex involving other chaperones and foldases that together ensure protein quality control. TXNDC5 interfaces with the redox system impacting the oxidative environment necessary for correct protein folding. By contributing to this complex system TXNDC5 helps prevent the accumulation of misfolded proteins and maintains the integrity of cellular function.

Pathways

TXNDC5 plays a role in the protein folding pathway which is vital to maintaining cellular stability. In addition its involvement in the response to unfolded protein responses signifies its importance in stress-related pathways. TXNDC5 often interacts with other proteins such as PDI (Protein Disulfide Isomerase) and Calreticulin which are also important in protein folding and cellular stress responses. These pathways are essential for adapting to changes in protein synthesis demands and mitigating the effects of cellular stress.

TXNDC5 has associations with conditions such as rheumatoid arthritis and certain cancers. Aberrant expression levels of TXNDC5 correlate with increased inflammatory responses in rheumatoid arthritis indicating its role in disease progression. In cancer overexpression of this protein has been observed suggesting a potential role in tumor growth and survival. Additionally TXNDC5 interacts with proteins like Hsp70 (Heat Shock Protein 70) which also plays a role in these disorders by assisting in protein folding under stress conditions thereby potentially influencing disease outcomes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.

See full target information TXNDC5

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:1034 PubMed41034905

2025

Interplay of axon regeneration genes and immune infiltration in spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Zimin Xiang,Dingxi Fang,Danping Gao,Qi Zhang,Yuxuan Zhang,Yuping Sun,Liyan Li,Xiaoqian Zhang,Jiaxin Li,Lingzhi Ding

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TXNDC5 antibody

Western blot - Anti-TXNDC5 antibody (AB227623)

Western blot - Anti-TXNDC5 antibody (AB227623)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise